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rdf:type |
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lifeskim:mentions |
umls-concept:C0019682,
umls-concept:C0019699,
umls-concept:C0019704,
umls-concept:C0025663,
umls-concept:C0032105,
umls-concept:C0035668,
umls-concept:C0181904,
umls-concept:C0220825,
umls-concept:C0596972,
umls-concept:C0728873,
umls-concept:C0969664,
umls-concept:C1510438,
umls-concept:C1521743,
umls-concept:C1704646
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pubmed:issue |
5
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pubmed:dateCreated |
1996-10-24
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pubmed:abstractText |
Three commercial assays for quantifying plasma human immunodeficiency virus type 1 (HIV-1) RNA were evaluated. The assays differed in their sample volumes, the means of preparing samples, and methods of amplification and detection. Plasma samples were obtained from 36 HIV-1-infected patients representing all stages of HIV-1 infection and were analyzed as coded specimens. Measurement of HIV-1 RNA baseline levels revealed no significant difference in sensitivity between the three assays. The assays were also applied to the quantitation of HIV-1 RNA levels in the plasma of patients who were changing their antiretroviral therapy. The changes measured in HIV-1 RNA levels in plasma in response to therapy were comparable by the three assays. No close correlation was found between the amount of HIV-1 RNA and the CD4 T-cell count; HIV-1 RNA assays were more sensitive than p24 antigen assays as an indicator of plasma viremia. Overall, the study demonstrates that all three quantitative assays for HIV-1 RNA can be used to measure the HIV-1 RNA copy number representing the HIV-1 viremia status in patients with HIV-1 infection. Since this copy number is likely to be useful in monitoring the effectiveness of antiviral therapy, these quantitative assays for HIV-1 RNA are ready to be built into clinical trials.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8727875-1506978,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8727875-1543566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8727875-1671424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8727875-1682345,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8727875-1691208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8727875-1706072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8727875-1714296,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8727875-1726172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8727875-1732501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8727875-1940882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8727875-2010639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8727875-2113075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8727875-2227421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8727875-2511447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8727875-2586564,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8727875-2780317,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8727875-2873436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8727875-2878129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8727875-3099912,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8727875-3163101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8727875-3305786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8727875-7529365,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8727875-7534858,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8727875-7683705,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8727875-7697440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8727875-7699034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8727875-7816094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8727875-7903317,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8727875-7915748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8727875-7963710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8727875-8094395,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8727875-8095981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8727875-8096089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8727875-8096582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8727875-8118788,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8727875-8150937,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8727875-8161438,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8727875-8366168
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0095-1137
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
34
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1058-64
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8727875-Adult,
pubmed-meshheading:8727875-Antiviral Agents,
pubmed-meshheading:8727875-Biological Markers,
pubmed-meshheading:8727875-Evaluation Studies as Topic,
pubmed-meshheading:8727875-Female,
pubmed-meshheading:8727875-HIV Infections,
pubmed-meshheading:8727875-HIV-1,
pubmed-meshheading:8727875-Humans,
pubmed-meshheading:8727875-Male,
pubmed-meshheading:8727875-Middle Aged,
pubmed-meshheading:8727875-Nucleic Acid Amplification Techniques,
pubmed-meshheading:8727875-RNA, Viral,
pubmed-meshheading:8727875-Reproducibility of Results,
pubmed-meshheading:8727875-Sensitivity and Specificity,
pubmed-meshheading:8727875-Viremia,
pubmed-meshheading:8727875-Virology
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pubmed:year |
1996
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pubmed:articleTitle |
Comparative evaluation of NASBA HIV-1 RNA QT, AMPLICOR-HIV monitor, and QUANTIPLEX HIV RNA assay, three methods for quantification of human immunodeficiency virus type 1 RNA in plasma.
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pubmed:affiliation |
Aids Referentielaboratorium, Vrije Universiteit Brussel, Belgium.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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