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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1996-12-3
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pubmed:abstractText |
S100 beta is a neurite extension factor that has been implicated in the development of neuritic plaques in Alzheimer's disease. We analyzed the expression of S100 beta and its encoding mRNA, using immunohistochemistry, enzyme-linked immunosorbent assay, and Northern blot analysis, in postmortem brain tissue from 26 neurologically normal patients, aged 1-80 years. Tissue levels of S100 beta and S100 beta mRNA, as well as the number of S100 beta-immunoreactive (S100 beta +) astrocytes, increased with advancing age (r = 0.60, p = 0.008; r = 0.65, p = 0.007: and r = 0.73, p = 0.001, respectively). In patients more than 60 years old, the number of S100 beta + astrocytes and the tissue levels of S100 beta and S100 beta mRNA were significantly higher than those in patients less than 60 years of age (p = 0.001, p = 0.035, and p = 0.047, respectively). All of these values, however, were significantly less than those found in Alzheimer patients (p < 0.05 or better). Our findings, together with the known functions of S100 beta, suggest that age-related increases in S100 beta expression are important in the pathogenesis of Alzheimer's disease and may explain in part the increased incidence of this disease with advancing age.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0197-4580
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
359-63
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:8725896-Adolescent,
pubmed-meshheading:8725896-Adult,
pubmed-meshheading:8725896-Age Distribution,
pubmed-meshheading:8725896-Aged,
pubmed-meshheading:8725896-Aging,
pubmed-meshheading:8725896-Alzheimer Disease,
pubmed-meshheading:8725896-Astrocytes,
pubmed-meshheading:8725896-Brain,
pubmed-meshheading:8725896-Child,
pubmed-meshheading:8725896-Child, Preschool,
pubmed-meshheading:8725896-Cytokines,
pubmed-meshheading:8725896-Female,
pubmed-meshheading:8725896-Humans,
pubmed-meshheading:8725896-Immunohistochemistry,
pubmed-meshheading:8725896-Infant,
pubmed-meshheading:8725896-Male,
pubmed-meshheading:8725896-Middle Aged,
pubmed-meshheading:8725896-RNA, Messenger
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pubmed:articleTitle |
Human brain S100 beta and S100 beta mRNA expression increases with age: pathogenic implications for Alzheimer's disease.
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pubmed:affiliation |
Arkansas Children's Hospital Research Center, Little Rock, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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