Linked Life Data

8724175

Source:http://linkedlifedata.com/resource/pubmed/id/8724175

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1996-12-3
pubmed:abstractText
Sufficient data exist indicating that testosterone (T) or metabolites of T, i.e., dihydrotestosterone (DHT) and estrogen (E), induce aggressive behavior. The effects of T have also been shown to be suppressed by concurrent administration of progesterone (P). It is unknown if the effects of P are exerted on T directly or upon the T metabolites. The objective of this experiment was to evaluate the inhibitory effects of P on aggression induced by T and T metabolites. Seven male mice were randomly allocated to one of the following treatment groups: castration (C), C + T, C + 5 alpha-dihydrotestosterone (DHT), C + estrogen (E), C + DHT + E (DE), T + P, and DE + P. The males were then placed with androgenized females in three 10-min trials to determine the effects of each treatment on hormone induced aggression. The degree of aggressive behavior displayed was measured by number of trials where attacks occurred (N), mean latency to attack (L), frequency of attacks (AF), duration of attacks (D), and a composite index score (INDEX). All androgen treated groups showed significantly higher degrees of aggression compared to C and T + P animals. P inhibited aggression in T-treated males but did not inhibit aggression in the DE treated group. The data suggest that P inhibits the aggressive effects of T by acting on receptors of the metabolite-producing enzymes or by direct competitive binding for 5 alpha-reductase.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0018-506X
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
22-5
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Progesterone does not inhibit aggression induced by testosterone metabolites in castrated male mice.
pubmed:affiliation
Department OBS/GYN, University of Auckland, New Zealand.
pubmed:publicationType
Journal Article