Linked Life Data

872362

Source:http://linkedlifedata.com/resource/pubmed/id/872362

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1977-8-25
pubmed:abstractText
Sera from forty-nine patients with atopic allergy were tested for the presence of circulating immune complexes by the sensitive, quantitative Clq assay. Compared to twenty-five normal individuals the atopic patients had significantly higher mean values of Clq reactive material, expressed as Clq inhibition values. The highest mean values were seen in the group (twenty-one patients) who had been on long term maintenance immunotherapy for 5 or more years. When positive sera were fractionated by ultracentrifugation on sucrose density gradients, the Clq reactive material was found in intermediate (7S-19S) and heavy (greater than 19S) regions. The heavy material contained both IgM and IgG. It is suggested that the IgG antibodies known to be produced by chronic hyposensitization procedures in allergic individuals may circulate in the serum as antibody-allergen immune complexes, and could carry out their blocking action in this form.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0009-9090
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
167-71
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1977
pubmed:articleTitle
Circulating immune complexes in patients with atopic allergy.
pubmed:publicationType
Journal Article