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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1996-11-12
|
| pubmed:abstractText |
This is a pilot retrospective study to investigate the factors that may affect the collection of peripheral blood progenitor cells (PBPC). Sixty-nine PBPC harvests in 18 cancer patients (median age 39.5; 8 males and 10 females) were performed during marrow recovery after chemotherapy and hematopoietic growth factors. Median number of nucleated cells (MNC) collected were 13.3 (range 2.3-44.5) x 10(9) per session. Median CFU-GM was 362 colonies (range 63-1,720) per 500,000 MNC. Neither sex, body weight, diagnosis, nor the number of days into leukapheresis was significantly associated with MNC and CFU-GM. Older patients tend to have higher CFU-GM in the PBPC harvests (P = .0437). Higher WBC on the day of harvest is significantly associated with higher yield of MNC after leukapheresis (P < .0001). Patients without any evidence of disease have significantly higher yield of MNC than those having local/distant metastases with or without marrow involvement (P = .0302 and .0446). For patients with metastatic disease, those with bone marrow involvement tend to have higher CFU-GM than those without bone marrow involvement although the difference is not statistically significant (P = .0559). Those patients who have received only one, or three and more chemotherapy regimens have a higher yield of MNC than those who have only two previous chemotherapy regimens (P = .036 and .0324). The mechanism of PBPC mobilization is also discussed. In view of the limited patient number in this study, the results should be confirmed by larger studies.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0733-2459
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
11
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
23-6
|
| pubmed:dateRevised |
2005-7-26
|
| pubmed:meshHeading |
pubmed-meshheading:8722718-Adolescent,
pubmed-meshheading:8722718-Adult,
pubmed-meshheading:8722718-Cell Count,
pubmed-meshheading:8722718-Colony-Forming Units Assay,
pubmed-meshheading:8722718-Female,
pubmed-meshheading:8722718-Granulocytes,
pubmed-meshheading:8722718-Hematopoietic Stem Cells,
pubmed-meshheading:8722718-Humans,
pubmed-meshheading:8722718-Leukapheresis,
pubmed-meshheading:8722718-Macrophages,
pubmed-meshheading:8722718-Male,
pubmed-meshheading:8722718-Middle Aged,
pubmed-meshheading:8722718-Neoplasms,
pubmed-meshheading:8722718-Pilot Projects,
pubmed-meshheading:8722718-Retrospective Studies,
pubmed-meshheading:8722718-Risk Factors
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Determining factors for the outcome of peripheral blood progenitor cells harvests.
|
| pubmed:affiliation |
Division of Oncology/Hematology, Texas Tech University, Lubbock 79430, USA.
|
| pubmed:publicationType |
Journal Article
|