Linked Life Data

8720297

Source:http://linkedlifedata.com/resource/pubmed/id/8720297

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1997-1-23
pubmed:abstractText
A series of rigid compounds--derivatives of 2,2-diphenyl-[1,3]-dioxolan-4-ylmethyl-dimethylamine methiodide (1b)--has been synthesized and tested to evaluate affinity and selectivity for M1, M2, and M3 muscarinic receptors. The stereochemistry of the annulation does not influence the activity; the optimal distance between nitrogen and the benzhydryl group seems to be that with the nitrogen in the rigid ring (2b) or the nitrogen directly bound at the cyclopentane nucleus (9b, 11b). The different structure-activity relationships between tertiary amines (a series) and the corresponding quartnerary salts (b series) suggest a different binding to the receptor sites.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0004-4172
pubmed:author
pubmed:issnType
Print
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
99-105
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Bicyclic dioxolanes as potential antimuscarinic agents.
pubmed:affiliation
Dipartimento di Scienze Chimiche, Università di Camerino, Italy.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't