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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1996-9-10
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pubmed:abstractText |
The present work was undertaken to test whether cytoskeletal components are involved in the control of rat-liver carnitine palmitoyltransferase I (CPT-I) activity by cellular effectors. The microtubule stabilizer taxol abolished the changes in CPT-I activity induced by the effectors tested. Taxol also prevented OA-induced shrinkage of hepatocytes as well as the enhanced release of lactate dehydrogenase from digitonin-permeabilized hepatocytes. On the basis of its relative sensitivity to tautomycin and OA, the modulation of CPT-I activity seemed to involve mostly protein phosphatase 1. These data suggest that the short-term control of hepatic CPT-I by cellular effectors may involve modulation of interactions between CPT-I and cytoskeletal components.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antifungal Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Bucladesine,
http://linkedlifedata.com/resource/pubmed/chemical/Carnitine O-Palmitoyltransferase,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Ethers, Cyclic,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamine,
http://linkedlifedata.com/resource/pubmed/chemical/Okadaic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Paclitaxel,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoprotein Phosphatases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Phosphatase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrans,
http://linkedlifedata.com/resource/pubmed/chemical/Spiro Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Vanadates,
http://linkedlifedata.com/resource/pubmed/chemical/tautomycin
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
25
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pubmed:volume |
224
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
754-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:8713118-Animals,
pubmed-meshheading:8713118-Antifungal Agents,
pubmed-meshheading:8713118-Bucladesine,
pubmed-meshheading:8713118-Carnitine O-Palmitoyltransferase,
pubmed-meshheading:8713118-Cells, Cultured,
pubmed-meshheading:8713118-Cytoskeleton,
pubmed-meshheading:8713118-Enzyme Inhibitors,
pubmed-meshheading:8713118-Ethers, Cyclic,
pubmed-meshheading:8713118-Glutamine,
pubmed-meshheading:8713118-Liver,
pubmed-meshheading:8713118-Male,
pubmed-meshheading:8713118-Microtubules,
pubmed-meshheading:8713118-Okadaic Acid,
pubmed-meshheading:8713118-Paclitaxel,
pubmed-meshheading:8713118-Phosphoprotein Phosphatases,
pubmed-meshheading:8713118-Protein Phosphatase 1,
pubmed-meshheading:8713118-Pyrans,
pubmed-meshheading:8713118-Rats,
pubmed-meshheading:8713118-Rats, Wistar,
pubmed-meshheading:8713118-Spiro Compounds,
pubmed-meshheading:8713118-Vanadates
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pubmed:year |
1996
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pubmed:articleTitle |
Are cytoskeletal components involved in the control of hepatic carnitine palmitoyltransferase I activity?
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pubmed:affiliation |
Department of Biochemistry and Molecular Biology I, Faculty of Biology, Complutense University, Madrid, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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