Linked Life Data

8699244

Source:http://linkedlifedata.com/resource/pubmed/id/8699244

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
14
pubmed:dateCreated
1996-8-30
pubmed:abstractText
Conduction block is a mechanism of activity-dependent neuronal plasticity, but little is known about its possible neuromodulation. Extensive activity in leech touch (T), pressure (P), and nociceptive (N) mechanosensory neurons results in conduction block of their minor receptive fields. We have examined whether the duration of conduction block could be modulated by the serotonergic Retzius neurons or by application of serotonin (5-HT). Activation of one Retzius cell reduced the duration of conduction block in T and P cell posterior fields, but their anterior fields and N cell fields were unaffected. Perfusion with 5-HT had stronger effects, reducing the duration of conduction block in T, P, and lateral N cells in the posterior fields and either reducing or more often enhancing the expression of conduction block in anterior fields. The effects of 5-HT on posterior fields were blocked by the nonspecific 5-HT antagonist methysergide and were partly suppressed by the 5-HT2 antagonist ketanserin. To determine the site of 5-HT action, the central ganglion or peripheral skin was perfused independently. T and to a greater extent P cells showed a preferential sensitivity to application of 5-HT onto the central ganglion. Interestingly, medial N cells exhibited a progressive decrease in the duration of conduction block during repeated trials ("wind-up") that was unaffected by 5-HT. We conclude that secretion of 5-HT by the Retzius cells has a central modulatory effect on the duration of conduction block in T, P, and lateral N cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0270-6474
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4335-43
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Modulation of conduction block in leech mechanosensory neurons.
pubmed:affiliation
Department of Biology, McGill University, Montréal, Québec, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't