| pubmed-article:8698385 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8698385 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:8698385 | lifeskim:mentions | umls-concept:C1257890 | lld:lifeskim |
| pubmed-article:8698385 | lifeskim:mentions | umls-concept:C0007452 | lld:lifeskim |
| pubmed-article:8698385 | lifeskim:mentions | umls-concept:C0175630 | lld:lifeskim |
| pubmed-article:8698385 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:8698385 | lifeskim:mentions | umls-concept:C0443172 | lld:lifeskim |
| pubmed-article:8698385 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8698385 | pubmed:dateCreated | 1996-9-5 | lld:pubmed |
| pubmed-article:8698385 | pubmed:abstractText | Bovine tuberculosis is a threat to animal and human health in several countries. Greater understanding of the immunology of the disease is required to develop improved tests and vaccines. This study has used a model of bovine tuberculosis, established in the natural host, to investigate the dynamic changes that occur in the circulating T-cell subpopulations after infection. When the phenotypic composition of the peripheral blood lymphocytes was determined pre- and post-experimental infection, the response to disease comprised three phases. Firstly, the WC1/gamma delta T cells decreased and then increased, suggesting localization to developing lesions and clonal expansion. Secondly, the CD4:CD8 ratio increased. Thirdly, the CD4:CD8 ratio decreased to less than pre-infection measurements. The latter changes suggested sequential involvement of CD4 and then CD8 T cells. The proportion of cells expressing interleukin-2 receptor (IL-2R) also increased. Panels of T-cell clones were established at various stages post-infection and all clones that exhibited antigen responsiveness were phenotyped. T-cell clones from early infection were WC1/gamma delta and CD4 in phenotype, while CD8 clones appeared later in infection, eventually becoming dominant. Therefore, from in vivo and in vitro evidence, it was suggested that there is a dynamic progression in the T-cell subpopulations involved dominantly in responses to mycobacteria. | lld:pubmed |
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| pubmed-article:8698385 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8698385 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8698385 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8698385 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8698385 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:8698385 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:8698385 | pubmed:author | pubmed-author:CrockardA DAD | lld:pubmed |
| pubmed-article:8698385 | pubmed:author | pubmed-author:PollockJ MJM | lld:pubmed |
| pubmed-article:8698385 | pubmed:author | pubmed-author:NeillS DSD | lld:pubmed |
| pubmed-article:8698385 | pubmed:author | pubmed-author:CampbellD GDG | lld:pubmed |
| pubmed-article:8698385 | pubmed:author | pubmed-author:PollockD ADA | lld:pubmed |
| pubmed-article:8698385 | pubmed:author | pubmed-author:MackieD PDP | lld:pubmed |
| pubmed-article:8698385 | pubmed:author | pubmed-author:GirvinR MRM | lld:pubmed |
| pubmed-article:8698385 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8698385 | pubmed:volume | 87 | lld:pubmed |
| pubmed-article:8698385 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8698385 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8698385 | pubmed:pagination | 236-41 | lld:pubmed |
| pubmed-article:8698385 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8698385 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8698385 | pubmed:articleTitle | Dynamic changes in circulating and antigen-responsive T-cell subpopulations post-Mycobacterium bovis infection in cattle. | lld:pubmed |
| pubmed-article:8698385 | pubmed:affiliation | Veterinary Sciences Division, Department of Agriculture for Northern Ireland, Stormont, Belfast. | lld:pubmed |
| pubmed-article:8698385 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8698385 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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