Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1996-9-5
pubmed:abstractText
Bovine tuberculosis is a threat to animal and human health in several countries. Greater understanding of the immunology of the disease is required to develop improved tests and vaccines. This study has used a model of bovine tuberculosis, established in the natural host, to investigate the dynamic changes that occur in the circulating T-cell subpopulations after infection. When the phenotypic composition of the peripheral blood lymphocytes was determined pre- and post-experimental infection, the response to disease comprised three phases. Firstly, the WC1/gamma delta T cells decreased and then increased, suggesting localization to developing lesions and clonal expansion. Secondly, the CD4:CD8 ratio increased. Thirdly, the CD4:CD8 ratio decreased to less than pre-infection measurements. The latter changes suggested sequential involvement of CD4 and then CD8 T cells. The proportion of cells expressing interleukin-2 receptor (IL-2R) also increased. Panels of T-cell clones were established at various stages post-infection and all clones that exhibited antigen responsiveness were phenotyped. T-cell clones from early infection were WC1/gamma delta and CD4 in phenotype, while CD8 clones appeared later in infection, eventually becoming dominant. Therefore, from in vivo and in vitro evidence, it was suggested that there is a dynamic progression in the T-cell subpopulations involved dominantly in responses to mycobacteria.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8698385-1280936, http://linkedlifedata.com/resource/pubmed/commentcorrection/8698385-1354243, http://linkedlifedata.com/resource/pubmed/commentcorrection/8698385-1356931, http://linkedlifedata.com/resource/pubmed/commentcorrection/8698385-1374103, http://linkedlifedata.com/resource/pubmed/commentcorrection/8698385-1379984, http://linkedlifedata.com/resource/pubmed/commentcorrection/8698385-1412093, http://linkedlifedata.com/resource/pubmed/commentcorrection/8698385-1535340, http://linkedlifedata.com/resource/pubmed/commentcorrection/8698385-1538155, http://linkedlifedata.com/resource/pubmed/commentcorrection/8698385-1586062, http://linkedlifedata.com/resource/pubmed/commentcorrection/8698385-1612754, http://linkedlifedata.com/resource/pubmed/commentcorrection/8698385-1623796, http://linkedlifedata.com/resource/pubmed/commentcorrection/8698385-1684572, http://linkedlifedata.com/resource/pubmed/commentcorrection/8698385-1692650, http://linkedlifedata.com/resource/pubmed/commentcorrection/8698385-1713198, http://linkedlifedata.com/resource/pubmed/commentcorrection/8698385-1727865, http://linkedlifedata.com/resource/pubmed/commentcorrection/8698385-1826600, http://linkedlifedata.com/resource/pubmed/commentcorrection/8698385-1971793, http://linkedlifedata.com/resource/pubmed/commentcorrection/8698385-2145360, http://linkedlifedata.com/resource/pubmed/commentcorrection/8698385-2443047, http://linkedlifedata.com/resource/pubmed/commentcorrection/8698385-2450033, http://linkedlifedata.com/resource/pubmed/commentcorrection/8698385-2464638, http://linkedlifedata.com/resource/pubmed/commentcorrection/8698385-2524098, http://linkedlifedata.com/resource/pubmed/commentcorrection/8698385-2526925, http://linkedlifedata.com/resource/pubmed/commentcorrection/8698385-3057717, http://linkedlifedata.com/resource/pubmed/commentcorrection/8698385-3109112, http://linkedlifedata.com/resource/pubmed/commentcorrection/8698385-3114143, http://linkedlifedata.com/resource/pubmed/commentcorrection/8698385-3114383, http://linkedlifedata.com/resource/pubmed/commentcorrection/8698385-3151440, http://linkedlifedata.com/resource/pubmed/commentcorrection/8698385-6602861, http://linkedlifedata.com/resource/pubmed/commentcorrection/8698385-7519175, http://linkedlifedata.com/resource/pubmed/commentcorrection/8698385-7678924, http://linkedlifedata.com/resource/pubmed/commentcorrection/8698385-7753173, http://linkedlifedata.com/resource/pubmed/commentcorrection/8698385-7816142, http://linkedlifedata.com/resource/pubmed/commentcorrection/8698385-7824893, http://linkedlifedata.com/resource/pubmed/commentcorrection/8698385-7890378, http://linkedlifedata.com/resource/pubmed/commentcorrection/8698385-7960123, http://linkedlifedata.com/resource/pubmed/commentcorrection/8698385-8073627, http://linkedlifedata.com/resource/pubmed/commentcorrection/8698385-8125515, http://linkedlifedata.com/resource/pubmed/commentcorrection/8698385-8143120, http://linkedlifedata.com/resource/pubmed/commentcorrection/8698385-8146439, http://linkedlifedata.com/resource/pubmed/commentcorrection/8698385-8160359, http://linkedlifedata.com/resource/pubmed/commentcorrection/8698385-8298954, http://linkedlifedata.com/resource/pubmed/commentcorrection/8698385-8310650, http://linkedlifedata.com/resource/pubmed/commentcorrection/8698385-8310658
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0019-2805
pubmed:author
pubmed:issnType
Print
pubmed:volume
87
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
236-41
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Dynamic changes in circulating and antigen-responsive T-cell subpopulations post-Mycobacterium bovis infection in cattle.
pubmed:affiliation
Veterinary Sciences Division, Department of Agriculture for Northern Ireland, Stormont, Belfast.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't