Linked Life Data

8690789

Source:http://linkedlifedata.com/resource/pubmed/id/8690789

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1996-8-26
pubmed:abstractText
To examine the role of alterations in myofibrillar function in human dilated cardiomyopathies, we determined isometric tension-calcium relations in permeabilized myocytesized myofibrillar preparations (n = 16) obtained from left ventricular biopsies from nine patients with dilated cardiomyopathy (DCM) during cardiac transplantation or left ventricular assist device implantation. Similar preparations (n = 10) were obtained from six normal hearts used for cardiac transplantation. Passive and maximal Ca2+-activated tensions were similar for the two groups. However, the calcium sensitivity of isometric tension was increased in DCM compared to nonfailing preparations ([Ca2+]50=2.46+/-0.49 microM vs 3.24+/-0.51 microM, P < 0.001). In vitro treatment with the catalytic subunit of protein kinase A (PKA) decreased calcium sensitivity of tension to a greater degree in failing than in normal preparations. Further, isometric tension-calcium relations in failing and normal myofibrillar preparations were similar after PKA treatment. These findings suggest that the increased calcium sensitivity of isometric tension in DCM may be due at least in part to a reduction of the beta-adrenergically mediated (PKA-dependent) phosphorylation of myofibrillar regulatory proteins such as troponin I and/or C-protein.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8690789-1185677, http://linkedlifedata.com/resource/pubmed/commentcorrection/8690789-1311223, http://linkedlifedata.com/resource/pubmed/commentcorrection/8690789-1311717, http://linkedlifedata.com/resource/pubmed/commentcorrection/8690789-1348975, http://linkedlifedata.com/resource/pubmed/commentcorrection/8690789-13860702, http://linkedlifedata.com/resource/pubmed/commentcorrection/8690789-1451254, http://linkedlifedata.com/resource/pubmed/commentcorrection/8690789-1533180, http://linkedlifedata.com/resource/pubmed/commentcorrection/8690789-1568299, http://linkedlifedata.com/resource/pubmed/commentcorrection/8690789-1572030, http://linkedlifedata.com/resource/pubmed/commentcorrection/8690789-1572051, http://linkedlifedata.com/resource/pubmed/commentcorrection/8690789-1576741, http://linkedlifedata.com/resource/pubmed/commentcorrection/8690789-1653120, http://linkedlifedata.com/resource/pubmed/commentcorrection/8690789-1735148, http://linkedlifedata.com/resource/pubmed/commentcorrection/8690789-1825828, http://linkedlifedata.com/resource/pubmed/commentcorrection/8690789-1884474, http://linkedlifedata.com/resource/pubmed/commentcorrection/8690789-1934353, http://linkedlifedata.com/resource/pubmed/commentcorrection/8690789-1934363, http://linkedlifedata.com/resource/pubmed/commentcorrection/8690789-2204499, http://linkedlifedata.com/resource/pubmed/commentcorrection/8690789-2419483, http://linkedlifedata.com/resource/pubmed/commentcorrection/8690789-2535795, http://linkedlifedata.com/resource/pubmed/commentcorrection/8690789-3183055, http://linkedlifedata.com/resource/pubmed/commentcorrection/8690789-3231093, http://linkedlifedata.com/resource/pubmed/commentcorrection/8690789-3366782, http://linkedlifedata.com/resource/pubmed/commentcorrection/8690789-3608112, http://linkedlifedata.com/resource/pubmed/commentcorrection/8690789-3719928, http://linkedlifedata.com/resource/pubmed/commentcorrection/8690789-3839239, http://linkedlifedata.com/resource/pubmed/commentcorrection/8690789-588245, http://linkedlifedata.com/resource/pubmed/commentcorrection/8690789-6189421, http://linkedlifedata.com/resource/pubmed/commentcorrection/8690789-6283349, http://linkedlifedata.com/resource/pubmed/commentcorrection/8690789-7473784, http://linkedlifedata.com/resource/pubmed/commentcorrection/8690789-7534662, http://linkedlifedata.com/resource/pubmed/commentcorrection/8690789-7648662, http://linkedlifedata.com/resource/pubmed/commentcorrection/8690789-7728995, http://linkedlifedata.com/resource/pubmed/commentcorrection/8690789-7730787, http://linkedlifedata.com/resource/pubmed/commentcorrection/8690789-7758155, http://linkedlifedata.com/resource/pubmed/commentcorrection/8690789-7758157, http://linkedlifedata.com/resource/pubmed/commentcorrection/8690789-7895342, http://linkedlifedata.com/resource/pubmed/commentcorrection/8690789-8001274, http://linkedlifedata.com/resource/pubmed/commentcorrection/8690789-8028019, http://linkedlifedata.com/resource/pubmed/commentcorrection/8690789-8118949, http://linkedlifedata.com/resource/pubmed/commentcorrection/8690789-8118962, http://linkedlifedata.com/resource/pubmed/commentcorrection/8690789-8156643, http://linkedlifedata.com/resource/pubmed/commentcorrection/8690789-8281642, http://linkedlifedata.com/resource/pubmed/commentcorrection/8690789-8381412, http://linkedlifedata.com/resource/pubmed/commentcorrection/8690789-8417846, http://linkedlifedata.com/resource/pubmed/commentcorrection/8690789-8419023
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0021-9738
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
98
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
167-76
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
More...