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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1996-8-28
|
| pubmed:abstractText |
Forty-five subjects (41 women and 4 men) in long-stay and medium-stay facilities, aged 74 to 95 years (mean 86.4 years), with 25-hydroxy-vitamin D levels less than 12 ng/ml, were treated for six consecutive months with two tablets per day of a preparation containing vitamin D3 (800 IU/day) and calcium carbonate (1 g elemental calcium/day). Serum levels of 25-hydroxy-vitamin D were very low at baseline (5.6 +/- 0.4 ng/ml) and rose significantly under treatment, to normal values, 33.2 +/- 1.2 and 40.9 +/- 2.1 ng/ml after three and six months, respectively (p < 0.001 for both comparisons). Serum calcium increased significantly, by 4.5% (p < 0.001) during the first three months, and remained at a plateau thereafter. Corrected serum calcium rose by 8.9% (p < 0.001) during the trial. No patient developed hypercalcemia. Serum parathyroid hormone levels, which were elevated at baseline (71.6 +/- 5.8 pg/ml; normal, 12 to 54 pg/ml), decreased gradually and significantly throughout the treatment period, by 43.0% and 67.1% after three and six months, respectively (p < 0.001 for both comparisons). Serum alkaline phosphatase activity fell concomitantly, by 9.9% after three months (p < 0.01) and 36.5% after six months (p < 0.001). In conclusion, the preparation used in our study is effective in correcting both the vitamin D deficiency that is prevalent in elderly institutionalized patients and the resultant increase in bone turnover.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alkaline Phosphatase,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Carbonate,
http://linkedlifedata.com/resource/pubmed/chemical/Parathyroid Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Vitamin D
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
1169-8446
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
63
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
135-40
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8689285-Administration, Oral,
pubmed-meshheading:8689285-Age Factors,
pubmed-meshheading:8689285-Aged,
pubmed-meshheading:8689285-Aged, 80 and over,
pubmed-meshheading:8689285-Alkaline Phosphatase,
pubmed-meshheading:8689285-Calcium,
pubmed-meshheading:8689285-Calcium Carbonate,
pubmed-meshheading:8689285-Dose-Response Relationship, Drug,
pubmed-meshheading:8689285-Drug Therapy, Combination,
pubmed-meshheading:8689285-Female,
pubmed-meshheading:8689285-Follow-Up Studies,
pubmed-meshheading:8689285-Humans,
pubmed-meshheading:8689285-Hyperparathyroidism, Secondary,
pubmed-meshheading:8689285-Hypocalcemia,
pubmed-meshheading:8689285-Institutionalization,
pubmed-meshheading:8689285-Male,
pubmed-meshheading:8689285-Parathyroid Hormone,
pubmed-meshheading:8689285-Retrospective Studies,
pubmed-meshheading:8689285-Vitamin D,
pubmed-meshheading:8689285-Vitamin D Deficiency
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Biochemical effects of calcium and vitamin D supplementation in elderly, institutionalized, vitamin D-deficient patients.
|
| pubmed:affiliation |
National Institute for Health and Medical Research (INSERM) unit 403, Edouard Herriot Hospital, Lyon, France.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial
|