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| pubmed-article:8675631 | lifeskim:mentions | umls-concept:C1135183 | lld:lifeskim |
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| pubmed-article:8675631 | lifeskim:mentions | umls-concept:C0596901 | lld:lifeskim |
| pubmed-article:8675631 | lifeskim:mentions | umls-concept:C0040715 | lld:lifeskim |
| pubmed-article:8675631 | lifeskim:mentions | umls-concept:C0897757 | lld:lifeskim |
| pubmed-article:8675631 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:8675631 | lifeskim:mentions | umls-concept:C1522702 | lld:lifeskim |
| pubmed-article:8675631 | lifeskim:mentions | umls-concept:C1417608 | lld:lifeskim |
| pubmed-article:8675631 | lifeskim:mentions | umls-concept:C1417609 | lld:lifeskim |
| pubmed-article:8675631 | lifeskim:mentions | umls-concept:C0213574 | lld:lifeskim |
| pubmed-article:8675631 | lifeskim:mentions | umls-concept:C0038891 | lld:lifeskim |
| pubmed-article:8675631 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:8675631 | lifeskim:mentions | umls-concept:C0599718 | lld:lifeskim |
| pubmed-article:8675631 | lifeskim:mentions | umls-concept:C0599813 | lld:lifeskim |
| pubmed-article:8675631 | lifeskim:mentions | umls-concept:C0599893 | lld:lifeskim |
| pubmed-article:8675631 | lifeskim:mentions | umls-concept:C0599946 | lld:lifeskim |
| pubmed-article:8675631 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:8675631 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:8675631 | pubmed:dateCreated | 1996-8-13 | lld:pubmed |
| pubmed-article:8675631 | pubmed:abstractText | Surfactant has been shown to inhibit the production of reactive oxygen intermediates by various cells including alveolar macrophages and peripheral blood neutrophils. Superoxide O2-. production by the respiratory burst oxidase in isolated plasma membranes prepared from PMA-treated human neutrophils was significantly attenuated by prior treatment with native porcine surfactant. The effect was concentration dependent with half-maximal inhibition seen at approximately 0.050 mg surfactant phospholipid/ml. Kinetic analyses of the membrane-bound enzyme prepared from neutrophils stimulated by PMA in the presence or absence of surfactant demonstrated that surfactant treatment led to a decrease in the maximal velocity of O2-. production when NADPH was used as substrate, but there was no effect on enzyme substrate affinity. Immunoblotting studies demonstrated that surfactant treatment induced a decrease in the association of two oxidase components, p47phox and p67phox, with the isolated plasma membrane. In contrast, surfactant treatment of the cells did not alter the phosphorylation of p47phox. A mixture of phospholipids (phosphatidylcholine and phosphatidylglycerol in a 7:3 ratio) showed similar inhibition of the PMA-induced O2-. generation. Taken together, these data suggest the mechanism of surfactant-induced inhibition of O2-. production by human neutrophils involves attenuation of translocation of cytosolic components of the respiratory burst oxidase to the plasma membrane. The phospholipid components of surfactant appear to play a significant role in this mechanism. | lld:pubmed |
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| pubmed-article:8675631 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:8675631 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:8675631 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8675631 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:8675631 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:8675631 | pubmed:author | pubmed-author:SmithR MRM | lld:pubmed |
| pubmed-article:8675631 | pubmed:author | pubmed-author:ChanVV | lld:pubmed |
| pubmed-article:8675631 | pubmed:author | pubmed-author:SpraggR GRG | lld:pubmed |
| pubmed-article:8675631 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8675631 | pubmed:volume | 96 | lld:pubmed |
| pubmed-article:8675631 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8675631 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8675631 | pubmed:pagination | 2654-60 | lld:pubmed |
| pubmed-article:8675631 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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