Linked Life Data

8673406

Source:http://linkedlifedata.com/resource/pubmed/id/8673406

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1996-8-15
pubmed:abstractText
Rats raised from weaning in a complex environment have an increased number of synapses per neuron in the visual cortex in comparison to animals housed in standard laboratory cages. Previous research has suggested that experience-dependent synaptic changes may be coordinated with changes in astrocytes. The present study used electron microscopy to examine astrocytic processes in the visual cortex of rats raised in a complex environment (EC) or in standard laboratory cages, either individually (IC) or in pairs (social condition, SC). Measurements of the surface density of astrocytic membrane in direct apposition to synaptic elements revealed that astrocytic processes have increased contact with synaptic elements within the visual cortex of EC rats in comparison to SC and IC animals. In contrast, other astrocytic size variables revealed no significant change in astrocytic processes per unit volume of tissue. Previous work has indicated no significant differences in synaptic density in these subjects. The specific increase in the contact between astrocytes and synapses suggests an experience-related enhancement of the astrocytic involvement in synaptic activity.
pubmed:grant
pubmed:keyword
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1074-7427
pubmed:author
pubmed:issnType
Print
pubmed:volume
65
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
48-56
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Ultrastructural evidence for increased contact between astrocytes and synapses in rats reared in a complex environment.
pubmed:affiliation
Department of Psychology, University of Illinois, Urbana 61801, USA.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Research Support, U.S. Gov't, P.H.S., Randomized Controlled Trial