Linked Life Data

8671660

Source:http://linkedlifedata.com/resource/pubmed/id/8671660

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1997-3-24
pubmed:abstractText
The product of the LAG-3 gene is a cell surface protein with significant homology to CD4. It has been suggested that it can serve as a functional equivalent of CD4 and account for the MHC class II-restricted responses which persist in CD4-deficient mice. To test this hypothesis, we have created CD4/LAG-3 double-deficient mice by successive homologous recombinations in embryonic stem cells. These animals turn out to be indistinguishable from CD4 single-deficient mice in their lymphocyte populations and responses that are controlled by MHC class II molecules. LAG-3 thus does not explain class II-restricted lymphocyte selection and function in the absence of CD4, strengthening the idea that these phenomena can occur independently of co-receptor signalling.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0953-8178
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
725-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
LAG-3 is not responsible for selecting T helper cells in CD4-deficient mice.
pubmed:affiliation
Institut de Génétique et de Biologie Moléculaire et Cellulaire (CNRS/INSERM/ULP), Strasbourg, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't