Linked Life Data

8670640

Source:http://linkedlifedata.com/resource/pubmed/id/8670640

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1996-11-19
pubmed:abstractText
Nine young right-handed men viewed colored pictures of people, scenes, and landscapes. Then, 24 hr later while undergoing PET scanning, they viewed previously studied (OLD) pictures in one type of scan, and previously not seen (NEW) pictures in another. The OLD-NEW subtraction of PET images indicates familiarity, and the NEW-OLD indicates novelty. Familiarity activations, signalling aspects of retrieval, were observed in the left and right frontal areas, and posterior regions bilaterally. Novelty activations were in the right limbic regions, and bilaterally in temporal and parietal regions, including area 37. These latter activations were located similarly to novelty activations in previous PET studies using visual words and auditory sentences, suggesting the existence of brain regions specializing in transmodal novelty assessment. The effects of novelty are seen both behaviorally and in replicable patterns of cortical and subcortical activation. We propose a 'novelty/encoding hypothesis': (1) novelty assessment represents an early stage of long-term memory encoding; (2) elaborate, meaning-based encoding processes operate on the incoming information to the extent of its novelty, and therefore (3) the probability of long-term storage of information varies directly with the novelty of the information.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1047-3211
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
71-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Novelty and familiarity activations in PET studies of memory encoding and retrieval.
pubmed:affiliation
Rotman Research Institute, Baycrest Centre for Geriatric Care, North York, Ontario, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't