Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
1996-7-26
|
pubmed:abstractText |
Over the past 6 years an unexpected way of making mutations in bacteria has challenged concepts of the genetic mechanisms behind evolution. Mechanistic studies of these so called 'adaptive' mutations are revealing a novel molecular mechanism involving DNA double-strand breaks, genetic recombination, probable DNA polymerase errors, and the possible suspension of mismatch repair during the reversion of a lac frameshift mutation in Escherichia coli. The molecular details of this process are altering our understanding of how mutations form in non-dividing cells.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
0027-5107
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
19
|
pubmed:volume |
350
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
69-76
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:8657199-Adaptation, Physiological,
pubmed-meshheading:8657199-Cell Division,
pubmed-meshheading:8657199-DNA Damage,
pubmed-meshheading:8657199-DNA Repair,
pubmed-meshheading:8657199-DNA Replication,
pubmed-meshheading:8657199-DNA-Directed DNA Polymerase,
pubmed-meshheading:8657199-Escherichia coli,
pubmed-meshheading:8657199-Frameshift Mutation,
pubmed-meshheading:8657199-Lac Operon,
pubmed-meshheading:8657199-Methylation,
pubmed-meshheading:8657199-Models, Genetic,
pubmed-meshheading:8657199-Mutagenesis,
pubmed-meshheading:8657199-Recombination, Genetic
|
pubmed:year |
1996
|
pubmed:articleTitle |
Recombination-dependent mutation in non-dividing cells.
|
pubmed:affiliation |
Department of Biochemistry, University of Alberta Faculty of Medicine, Edmonton, Canada.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|