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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1996-7-26
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pubmed:abstractText |
Formation of neuromuscular synapses requires a series of inductive interactions between growing motor axons and differentiating muscle cells, culminating in the precise juxtaposition of a highly specialized nerve terminal with a complex molecular structure on the postsynaptic muscle surface. The receptors and signaling pathways mediating these inductive interactions are not known. We have generated mice with a targeted disruption of the gene encoding MuSK, a receptor tyrosine kinase selectively localized to the postsynaptic muscle surface. Neuromuscular synapses do not form in these mice, suggesting a failure in the induction of synapse formation. Together with the results of an accompanying manuscript, our findings indicate that MuSK responds to a critical nerve-derived signal (agrin), and in turn activates signaling cascades responsible for all aspects of synapse formation, including organization of the postsynaptic membrane, synapse-specific transcription, and presynaptic differentiation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0092-8674
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pubmed:author |
pubmed-author:BowenD CDC,
pubmed-author:BurdenS JSJ,
pubmed-author:ComptonD LDL,
pubmed-author:DeChiaraT MTM,
pubmed-author:DiStefanoP SPS,
pubmed-author:GlassD JDJ,
pubmed-author:KinetzEE,
pubmed-author:ParkJ SJS,
pubmed-author:PoueymirouW TWT,
pubmed-author:RojasEE,
pubmed-author:SimmonsM VMV,
pubmed-author:SmithCC,
pubmed-author:ThomasSS,
pubmed-author:ValenzuelaD MDM,
pubmed-author:YancopoulosG DGD
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pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
85
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
501-12
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pubmed:dateRevised |
2011-9-22
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pubmed:meshHeading |
pubmed-meshheading:8653786-Agrin,
pubmed-meshheading:8653786-Animals,
pubmed-meshheading:8653786-Animals, Newborn,
pubmed-meshheading:8653786-Cell Differentiation,
pubmed-meshheading:8653786-Gene Deletion,
pubmed-meshheading:8653786-Gene Expression,
pubmed-meshheading:8653786-Genes, Lethal,
pubmed-meshheading:8653786-Mice,
pubmed-meshheading:8653786-Mice, Knockout,
pubmed-meshheading:8653786-Muscle, Skeletal,
pubmed-meshheading:8653786-Muscle Fibers, Skeletal,
pubmed-meshheading:8653786-Neuromuscular Junction,
pubmed-meshheading:8653786-Receptor Protein-Tyrosine Kinases,
pubmed-meshheading:8653786-Receptors, Cholinergic,
pubmed-meshheading:8653786-Signal Transduction,
pubmed-meshheading:8653786-Synapses,
pubmed-meshheading:8653786-Synaptic Membranes,
pubmed-meshheading:8653786-Transcription, Genetic
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pubmed:year |
1996
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pubmed:articleTitle |
The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo.
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pubmed:affiliation |
Regeneron Pharmaceuticals, Inc., Tarrytown, New York 10591, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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