Linked Life Data

8646732

Source:http://linkedlifedata.com/resource/pubmed/id/8646732

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1996-7-25
pubmed:abstractText
We report a series of 86 non-Hodgkin's lymphomas (NHL) studied cytogenetically in which two cases with a homogeneously staining region (HSR) located on chromosome 19 and on chromosome 1, respectively, were observed. The low incidence detected (2.3%) suggests that HSR are rare events in NHL. An oncogenetic amplification study was performed with probes for genes that are currently known to undergo amplification and with probes for two genes located on chromosome 19q (AKT2 and BCL-3). We detected no amplification except for AKT2 putative oncogene in the lymphoma in which the HSR was located on chromosome 19. Because amplification of AKT2 putative oncogene has been detected in ovarian carcinomas bearing HSR and in this case NHL, we believe that this gene may be implicated in the pathogenesis of other neoplasias in cooperation with other genes. Further investigation is needed to confirm the low incidence of HSR in NHL and the origin of the amplified material.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0165-4608
pubmed:author
pubmed:issnType
Print
pubmed:volume
87
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-3
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
Incidence of homogeneously staining regions in non-Hodgkin lymphomas.
pubmed:affiliation
Department of Genetics, Fundación Jiménez Díaz, Madrid, Spain.
pubmed:publicationType
Journal Article, Case Reports, Research Support, Non-U.S. Gov't