Linked Life Data

8643366

Source:http://linkedlifedata.com/resource/pubmed/id/8643366

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
33
pubmed:dateCreated
1996-7-17
pubmed:abstractText
Programmed translational frameshifting is a ubiquitous, though rare, mechanism of gene expression in prokaryotes and eukaryotes. Research on many such sites has led to a general understanding that frameshifting depends on slippage of one or two ribosome-bound tRNAs on the mRNA. We recently found an example of an efficient frameshift in the Ty3 retrotransposon of the yeast Saccharomyces cerevisiae which occurs without tRNA slippage. Frameshifting appears to occur by misplacement of aminoacyl-tRNA in the ribosomal A site. Most of the eight tRNAs which induce measurable amounts of +1 frameshifting are predicted to slip only very poorly. In fact, frameshifting by tRNA slippage appears an unusual event in yeast, and where it occurs depends on peptidyl-tRNAs which employ two-out-of-three decoding. In addition, frameshifting either by slippage or by aminoacyl-tRNA misplacement depends on adequate availability of the first +1 frame tRNA. We present two models to explain how the tRNA which reads the shifted frame codon could promote +1 translational frameshifting.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0261-3166
pubmed:author
pubmed:issnType
Print
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
190-3
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Peptidyl-tRNAs promote translational frameshifting.
pubmed:affiliation
Department of Biological Sciences/Program in Molecular and Cell Biology, University of Maryland, Baltimore 21228, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.