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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
1996-7-15
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pubmed:abstractText |
In 40 out of 99 patients (40.4%) with solid tumours of different tissue, but the same stage (IV), elevated serum levels of interleukin-10 were observed. The mean levels of the cytokine in patients with malignant melanoma (24.3 ng/ml), pancreatic (6.8 ng/ml) or gastric (6.3 ng/ml) adenocarcinoma were significantly higher than in healthy subjects (3.4 ng/ml) or in patients with uterine fibroma (1.7 ng/ml). Patients with colon (6.8 ng/ml) and renal (5.7 ng/ml) carcinoma had similar values of interleukin-10 but did not significantly differ from controls. Interleukin-10 is known to suppress the functions of both T lymphocytes and macrophages, working as a general dampener of the immune and inflammatory responses. The observation of increased circulating levels of interleukin-10 in cancer patients may have important implications for future investigations, immunological monitoring and therapeutic intervention on neoplastic patients, and suggests a mechanism for tumour cells escaping from immune surveillance.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0304-3835
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
24
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pubmed:volume |
104
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8640735-Adult,
pubmed-meshheading:8640735-Aged,
pubmed-meshheading:8640735-Female,
pubmed-meshheading:8640735-Humans,
pubmed-meshheading:8640735-Interleukin-10,
pubmed-meshheading:8640735-Male,
pubmed-meshheading:8640735-Middle Aged,
pubmed-meshheading:8640735-Neoplasm Staging,
pubmed-meshheading:8640735-Neoplasms,
pubmed-meshheading:8640735-Reference Values
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pubmed:year |
1996
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pubmed:articleTitle |
Increased interleukin-10 serum levels in patients with solid tumours.
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pubmed:affiliation |
Adoptive Immunotherapy Laboratory, IRCCS H San Raffaele, Milan, Italy.
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pubmed:publicationType |
Journal Article,
Comparative Study
|