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rdf:type |
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lifeskim:mentions |
umls-concept:C0063710,
umls-concept:C0205314,
umls-concept:C0332307,
umls-concept:C0567416,
umls-concept:C0679622,
umls-concept:C1149184,
umls-concept:C1334043,
umls-concept:C1416393,
umls-concept:C1416400,
umls-concept:C1420442,
umls-concept:C2348205
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pubmed:issue |
8
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pubmed:dateCreated |
1996-6-21
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pubmed:databankReference |
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pubmed:abstractText |
A novel member of the interleukin-1 receptor family has been cloned by polymerase chain reaction using degenerate oligonucleotide primers derived from regions of sequence conservation, using as template a yeast artificial chromosome known to contain both interleukin-1 (IL-1) receptors and T1/ST2. The new receptor, called IL-1 receptor-related protein or IL-1Rrp, fails to bind any of the known IL-1 ligands. A chimeric receptor, in which the IL-1Rrp cytoplasmic domain is fused to the extracellular and transmembrane regions of the IL-1 receptor, responds to IL-1 following transfection into COS cells by activation of NFkappaB and induction of IL-8 promoter function.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0021-9258
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
23
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pubmed:volume |
271
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3967-70
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:8626725-Amino Acid Sequence,
pubmed-meshheading:8626725-Animals,
pubmed-meshheading:8626725-Cell Line,
pubmed-meshheading:8626725-Cell Membrane,
pubmed-meshheading:8626725-Cercopithecus aethiops,
pubmed-meshheading:8626725-Cloning, Molecular,
pubmed-meshheading:8626725-Cytoplasm,
pubmed-meshheading:8626725-DNA Primers,
pubmed-meshheading:8626725-Humans,
pubmed-meshheading:8626725-Interleukin-18 Receptor alpha Subunit,
pubmed-meshheading:8626725-Interleukin-8,
pubmed-meshheading:8626725-Mice,
pubmed-meshheading:8626725-Molecular Sequence Data,
pubmed-meshheading:8626725-NF-kappa B,
pubmed-meshheading:8626725-Polymerase Chain Reaction,
pubmed-meshheading:8626725-Promoter Regions, Genetic,
pubmed-meshheading:8626725-Protein Biosynthesis,
pubmed-meshheading:8626725-Proteins,
pubmed-meshheading:8626725-Receptors, Interleukin-1,
pubmed-meshheading:8626725-Receptors, Interleukin-18,
pubmed-meshheading:8626725-Recombinant Fusion Proteins,
pubmed-meshheading:8626725-Sequence Homology, Amino Acid,
pubmed-meshheading:8626725-Transfection
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pubmed:year |
1996
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pubmed:articleTitle |
IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP.
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pubmed:affiliation |
Immunex Corporation, Seattle, Washington 98101, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study
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