Linked Life Data

8624488

Source:http://linkedlifedata.com/resource/pubmed/id/8624488

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pubmed-article:8624488pubmed:abstractTextModified citrus pectin (MCP) added to the media of cultured androgen-independent human prostatic JCA-1 cells reduced cell growth and correspondingly [3H]thymidine incorporation into DNA, which was correlated with the down-regulation of cyclin B and p34cdc2 MCP also induced distinct increases in specific endogenous phosphoproteins, including a cAMP-stimulated 52,000 (52-kDa) protein. Since metastatis has been inversely correlated with nm23 gene expression in some cancer cells and was reportedly inhibited by MCP in a rat prostate model, we investigated steady state level changes in the nm23 protein in JCA-1 cells and found it to be unexpectedly suppressed as a result of exposure to MCP.lld:pubmed
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pubmed-article:8624488pubmed:articleTitleChanges in cell growth, cyclin/kinase, endogenous phosphoproteins and nm23 gene expression in human prostatic JCA-1 cells treated with modified citrus pectin.lld:pubmed
pubmed-article:8624488pubmed:affiliationDepartment of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA.lld:pubmed
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pubmed-article:8624488pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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