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rdf:type |
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lifeskim:mentions |
umls-concept:C0007595,
umls-concept:C0007634,
umls-concept:C0017262,
umls-concept:C0031689,
umls-concept:C0031727,
umls-concept:C0079183,
umls-concept:C0086418,
umls-concept:C0205227,
umls-concept:C0332293,
umls-concept:C0392747,
umls-concept:C0443172,
umls-concept:C0937931,
umls-concept:C1522721,
umls-concept:C1709130
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pubmed:issue |
5
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pubmed:dateCreated |
1996-6-24
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pubmed:abstractText |
Modified citrus pectin (MCP) added to the media of cultured androgen-independent human prostatic JCA-1 cells reduced cell growth and correspondingly [3H]thymidine incorporation into DNA, which was correlated with the down-regulation of cyclin B and p34cdc2 MCP also induced distinct increases in specific endogenous phosphoproteins, including a cAMP-stimulated 52,000 (52-kDa) protein. Since metastatis has been inversely correlated with nm23 gene expression in some cancer cells and was reportedly inhibited by MCP in a rat prostate model, we investigated steady state level changes in the nm23 protein in JCA-1 cells and found it to be unexpectedly suppressed as a result of exposure to MCP.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CDC2 Protein Kinase,
http://linkedlifedata.com/resource/pubmed/chemical/CDK4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cdk4 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase 4,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclins,
http://linkedlifedata.com/resource/pubmed/chemical/Pectins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53,
http://linkedlifedata.com/resource/pubmed/chemical/pectin
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1039-9712
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
833-41
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:8624488-Animals,
pubmed-meshheading:8624488-CDC2 Protein Kinase,
pubmed-meshheading:8624488-Cell Division,
pubmed-meshheading:8624488-Citrus,
pubmed-meshheading:8624488-Cyclin D,
pubmed-meshheading:8624488-Cyclin-Dependent Kinase 4,
pubmed-meshheading:8624488-Cyclin-Dependent Kinases,
pubmed-meshheading:8624488-Cyclins,
pubmed-meshheading:8624488-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:8624488-Humans,
pubmed-meshheading:8624488-Male,
pubmed-meshheading:8624488-Neoplasm Metastasis,
pubmed-meshheading:8624488-Pectins,
pubmed-meshheading:8624488-Phosphoproteins,
pubmed-meshheading:8624488-Prostatic Neoplasms,
pubmed-meshheading:8624488-Proto-Oncogene Proteins,
pubmed-meshheading:8624488-Rats,
pubmed-meshheading:8624488-Tumor Cells, Cultured,
pubmed-meshheading:8624488-Tumor Suppressor Protein p53
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pubmed:year |
1995
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pubmed:articleTitle |
Changes in cell growth, cyclin/kinase, endogenous phosphoproteins and nm23 gene expression in human prostatic JCA-1 cells treated with modified citrus pectin.
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pubmed:affiliation |
Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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