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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1996-6-17
|
| pubmed:abstractText |
The purpose of this study was to determine the normal beta-human chorionic gonadotropin change within 24 hours after a medical abortion. Because a medical abortion creates a "miscarriage," these data can represent the serum beta-human chorionic gonadotropin changes that would occur with a complete spontaneous abortion. Knowledge of normal beta-human chorionic gonadotropin changes after a spontaneous abortion may help to differentiate within a 24-hour period a complete from an incomplete spontaneous abortion or an ectopic pregnancy.
|
| pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/Abortion, Drug Induced--complications,
http://linkedlifedata.com/resource/pubmed/keyword/Abortion, Induced--complications,
http://linkedlifedata.com/resource/pubmed/keyword/Americas,
http://linkedlifedata.com/resource/pubmed/keyword/Biology,
http://linkedlifedata.com/resource/pubmed/keyword/California,
http://linkedlifedata.com/resource/pubmed/keyword/Clinical Research,
http://linkedlifedata.com/resource/pubmed/keyword/Clinical Trials,
http://linkedlifedata.com/resource/pubmed/keyword/Developed Countries,
http://linkedlifedata.com/resource/pubmed/keyword/Diseases,
http://linkedlifedata.com/resource/pubmed/keyword/Endocrine System,
http://linkedlifedata.com/resource/pubmed/keyword/Family Planning,
http://linkedlifedata.com/resource/pubmed/keyword/Fertility Control, Postconception,
http://linkedlifedata.com/resource/pubmed/keyword/GONADOTROPINS, CHORIONIC,
http://linkedlifedata.com/resource/pubmed/keyword/Gonadotropins,
http://linkedlifedata.com/resource/pubmed/keyword/Hormones,
http://linkedlifedata.com/resource/pubmed/keyword/Misoprostol--side effects,
http://linkedlifedata.com/resource/pubmed/keyword/North America,
http://linkedlifedata.com/resource/pubmed/keyword/Northern America,
http://linkedlifedata.com/resource/pubmed/keyword/PREGNANCY, ECTOPIC,
http://linkedlifedata.com/resource/pubmed/keyword/PROSTAGLANDINS,
http://linkedlifedata.com/resource/pubmed/keyword/Physiology,
http://linkedlifedata.com/resource/pubmed/keyword/Pregnancy Complications,
http://linkedlifedata.com/resource/pubmed/keyword/Prospective Studies,
http://linkedlifedata.com/resource/pubmed/keyword/Prostaglandins, Synthetic,
http://linkedlifedata.com/resource/pubmed/keyword/Research Methodology,
http://linkedlifedata.com/resource/pubmed/keyword/Studies,
http://linkedlifedata.com/resource/pubmed/keyword/United States
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0002-9378
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
174
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
776-8
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:otherAbstract |
PIP: The purpose of the study was to determine the normal beta-human chorionic gonadotropin change within 24 hours after a medical abortion to differentiate a complete from an incomplete spontaneous abortion or an ectopic pregnancy. 171 English- and Spanish-speaking pregnant women were recruited for four prospective trials by the University of California, San Francisco. Three trials included women under 56 days' gestation and a fourth trial included women between 57 and 63 days' gestation. Patients from the 1st trial group received methotrexate 50 mg/sq. meter im, followed 3 days later by misoprostol 800 mcg vaginally. In the 2nd trial group, patients were randomized to receive methotrexate 50 mg/sq. meter im, followed by misoprostol or misoprostol alone. In the 3rd trial group, patients were randomized to receive methotrexate 50 mg/sq. meter im, followed by misoprostol 3 days later (group 1) or 7 days later (group 2). In the 4th trial group patients between 57 and 63 days' gestation received methotrexate 50 mg/square meter im followed 3 days later by misoprostol 800 mcg vaginally. 86 women met the criteria for evaluation of the change in serum beta-hCG levels on the day after misoprostol administration. 3 of these patients had incomplete abortion (1 immediate success and 2 delayed successes). The change in beta-hCG on the day after the initial misoprostol administration for these was -67%, -20%, and -19%, respectively. 48 women received the first dose of misoprostol 3 days after methotrexate and 38 women received misoprostol 7 days later. Subjects who had complete abortion after receiving methotrexate and a single dose of misoprostol had a decline in serum beta-hCG of 66% +or- 8%. All other subjects had a decline of 25% +or- 19% (p = .0001). An aborting pregnancy, if the abortion has occurred, should have a beta-hCG decrease of approximately 50% within about 24 hours. However, a patient with a serum beta-hCG level that has not declined approximately 50% over 24 hours is unlikely to have a complete abortion.
|
| pubmed:meshHeading |
pubmed-meshheading:8623820-Abortifacient Agents, Nonsteroidal,
pubmed-meshheading:8623820-Abortion, Induced,
pubmed-meshheading:8623820-Administration, Intravaginal,
pubmed-meshheading:8623820-Chorionic Gonadotropin, beta Subunit, Human,
pubmed-meshheading:8623820-Female,
pubmed-meshheading:8623820-Humans,
pubmed-meshheading:8623820-Injections, Intramuscular,
pubmed-meshheading:8623820-Methotrexate,
pubmed-meshheading:8623820-Misoprostol,
pubmed-meshheading:8623820-Pregnancy
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Change in serum beta-human chorionic gonadotropin after abortion with methotrexate and misoprostol.
|
| pubmed:affiliation |
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Magee-Womens Hospital, PA, USA.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
|