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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1996-6-5
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pubmed:abstractText |
gp34, which we had identified as a target molecule of the trans-activation by Tax of human T-cell leukemia virus type I (HTLV-I), has been found to bind OX40, a member of the tumor necrosis factor receptor family, resulting in growth stimulation of activated T cells. We here demonstrate that not only gp34 (OX40L), but also OX40 can be transcriptionally activated by Tax. Three Tax-producing human T-cell lines carrying the HTLV-I genome expressed OX40 on their surfaces. Furthermore, Tax-induced transcriptional activation of OX40 was shown in Tax-inducible JPX-9 cells. These results demonstrate that both OX40 and its ligand (gp34) are constitutively expressed on the surfaces of Tax-expressing T lymphocytes, suggesting that the OX40L/OX40 system contributes to growth stimulation of the virus-infected T cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD27,
http://linkedlifedata.com/resource/pubmed/chemical/Cadmium,
http://linkedlifedata.com/resource/pubmed/chemical/Cadmium Chloride,
http://linkedlifedata.com/resource/pubmed/chemical/Chlorides,
http://linkedlifedata.com/resource/pubmed/chemical/Culture Media, Conditioned,
http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, tax,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/OX40 Ligand,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, OX40,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/TNFRSF4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/TNFSF4 protein, human
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0910-5050
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
87
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
227-31
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:8613423-Antigens, CD27,
pubmed-meshheading:8613423-Cadmium,
pubmed-meshheading:8613423-Cadmium Chloride,
pubmed-meshheading:8613423-Chlorides,
pubmed-meshheading:8613423-Culture Media, Conditioned,
pubmed-meshheading:8613423-Gene Expression Regulation, Leukemic,
pubmed-meshheading:8613423-Gene Expression Regulation, Viral,
pubmed-meshheading:8613423-Gene Products, tax,
pubmed-meshheading:8613423-Human T-lymphotropic virus 1,
pubmed-meshheading:8613423-Humans,
pubmed-meshheading:8613423-Leukemia-Lymphoma, Adult T-Cell,
pubmed-meshheading:8613423-Membrane Glycoproteins,
pubmed-meshheading:8613423-Neoplasm Proteins,
pubmed-meshheading:8613423-OX40 Ligand,
pubmed-meshheading:8613423-Receptors, OX40,
pubmed-meshheading:8613423-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:8613423-T-Lymphocytes,
pubmed-meshheading:8613423-Transcriptional Activation,
pubmed-meshheading:8613423-Tumor Cells, Cultured
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pubmed:year |
1996
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pubmed:articleTitle |
Induction of OX40, a receptor of gp34, on T cells by trans-acting transcriptional activator, Tax, of human T-cell leukemia virus type I.
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pubmed:affiliation |
Department of Microbiology, Tohoku University School of Medicine, Sendai.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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