Linked Life Data

8609706

Source:http://linkedlifedata.com/resource/pubmed/id/8609706

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1996-5-29
pubmed:abstractText
The t(12;21)(p13;q22) is identified by routine cytogenetics in less than 0.05% of pediatric acute lymphoblastic leukemia (ALL) patients. This translocation encodes a TEL/AML-1 chimeric product comprising the helix-loop-helix domain of TEL, a member of the ETS-like family of transcription factors, fused to AML-1, the DNA-binding subunit of the AML-1/CBF beta transcription factor complex. Both TEL and AML-1 are involved in several myeloid leukemia-associated translocations with AML-1/CBF beta being altered in 20-30% of de novo acute myeloid leukemia (AML) cases. We now demonstrate that a TEL/AML1 chimeric transcript encoded by a cryptic t(12;21) is observed in 22% of pediatric ALL, making it the most common genetic lesion in these patients. Moreover, TEL/AML1 expression defined a distinct subgroup of patients characterized by an age between 1 and 10 years, B lineage immunophenotype, non-hyperdiploid DNA content and an excellent prognosis. These data demonstrate that molecular diagnostic approaches are invaluable in identifying clinically distinct subgroups, and that the AML1/CBF beta transcription complex is the most frequent target of chromosomal rearrangements in human leukemia.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0887-6924
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1985-9
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:8609706-Base Sequence, pubmed-meshheading:8609706-Child, pubmed-meshheading:8609706-Child, Preschool, pubmed-meshheading:8609706-Chromosomes, Human, Pair 12, pubmed-meshheading:8609706-Chromosomes, Human, Pair 21, pubmed-meshheading:8609706-Core Binding Factor Alpha 2 Subunit, pubmed-meshheading:8609706-DNA-Binding Proteins, pubmed-meshheading:8609706-Humans, pubmed-meshheading:8609706-Molecular Sequence Data, pubmed-meshheading:8609706-Neoplasm Proteins, pubmed-meshheading:8609706-Precursor Cell Lymphoblastic Leukemia-Lymphoma, pubmed-meshheading:8609706-Prognosis, pubmed-meshheading:8609706-Proto-Oncogene Proteins, pubmed-meshheading:8609706-Proto-Oncogene Proteins c-ets, pubmed-meshheading:8609706-Recombinant Fusion Proteins, pubmed-meshheading:8609706-Repressor Proteins, pubmed-meshheading:8609706-Transcription Factors, pubmed-meshheading:8609706-Translocation, Genetic
pubmed:year
1995
pubmed:articleTitle
TEL/AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis.
pubmed:affiliation
Department of Pathology and Laboratory Medicine, St Jude Children's Research Hospital, Memphis, TN, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't