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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1996-5-23
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pubmed:abstractText |
Murine monoclonal antibodies (MAbs) specific for toxic shock syndrome toxin 1 (TSST-1), a bacterial superantigen, showed the ability either to detect TSST-1 bound to histocompatibility locus antigen (HLA)-DR molecules or to inhibit TSST-1 binding to HLA-DR. A MAb capable of detecting DR-bound TSST-1 could also inhibit the toxin-induced activation of a T-cell receptor Vbeta15-expressing murine T-cell hybridoma. Alternatively, MAbs with specificity for the HLA-DR association site could present TSST-1 in vitro, stimulating CD4+ human T cells to proliferate. These functional activities correlated directly with with MAb specificity for HLA-DR versus T-cell receptor Vbeta interaction sites on TSST-1 as determined by reactivity with a panel of recombinant TSST-1 mutant molecules. Therefore, these MAbs discriminate the superantigen functional sites on the TSST-1 molecule and constitute reagents with the property of being potent modulators of the toxic activity of TSST-1.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8606069-1370682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8606069-1696937,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8606069-1706480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8606069-2206394,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8606069-2467343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8606069-3069202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8606069-3257201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8606069-3782792,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8606069-6166712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8606069-6200537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8606069-7519243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8606069-7594509,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8606069-7760008,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8606069-7901681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8606069-7913945,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8606069-7947690,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8606069-7997880,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8606069-8094737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8606069-8107781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8606069-8254210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8606069-8268150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8606069-8359928,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8606069-8397479,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8606069-8432600
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Toxins,
http://linkedlifedata.com/resource/pubmed/chemical/Enterotoxins,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DR Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/Superantigens,
http://linkedlifedata.com/resource/pubmed/chemical/enterotoxin F, Staphylococcal
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
64
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1133-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8606069-Animals,
pubmed-meshheading:8606069-Antibodies, Monoclonal,
pubmed-meshheading:8606069-Antibody Specificity,
pubmed-meshheading:8606069-Antigen Presentation,
pubmed-meshheading:8606069-Bacterial Toxins,
pubmed-meshheading:8606069-Binding Sites,
pubmed-meshheading:8606069-Enterotoxins,
pubmed-meshheading:8606069-Epitope Mapping,
pubmed-meshheading:8606069-HLA-DR Antigens,
pubmed-meshheading:8606069-Humans,
pubmed-meshheading:8606069-Mice,
pubmed-meshheading:8606069-Mice, Inbred BALB C,
pubmed-meshheading:8606069-Receptors, Antigen, T-Cell,
pubmed-meshheading:8606069-Staphylococcus aureus,
pubmed-meshheading:8606069-Superantigens,
pubmed-meshheading:8606069-T-Lymphocytes
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pubmed:year |
1996
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pubmed:articleTitle |
Delineation by use of specific monoclonal antibodies of the T-cell receptor and major histocompatibility complex interaction sites on the superantigen toxic shock syndrome toxin 1.
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pubmed:affiliation |
Nexstar Pharmaceuticals, Inc., Lakewood Colorado, 80214, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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