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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6575
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pubmed:dateCreated |
1996-5-8
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pubmed:abstractText |
Interleukin-4 (IL-4) is a pleiotropic lymphokine which plays an important role in the immune system. IL-4 activates two distinct signalling pathways through tyrosine phosphorylation of Stat6, a signal transducer and activator of transcription, and of a 170K protein called 4PS. To investigate the functional role of Stat6 in IL-4 signalling, we generated mice deficient in Stat6 by gene targeting. We report here that in the mutant mice, expression of CD23 and major histocompatibility complex (MHC) class II in resting B cells was not enhanced in response to IL-4. IL-4 induced B-cell proliferation costimulated by anti-IgM antibody was abolished. The T-cell proliferative response was also notably reduced. Furthermore, production of Th2 cytokines from T cells as well as IgE and IgG1 responses after nematode infection were profoundly reduced. These findings agreed with those obtained in IL-4 deficient mice or using antibodies to IL-4 and the IL-4 receptor. We conclude that Stat6 plays a central role in exerting IL-4 mediated biological responses.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Helminth,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class II,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin A,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin E,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, IgE,
http://linkedlifedata.com/resource/pubmed/chemical/STAT6 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Stat6 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0028-0836
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
380
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
627-30
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:8602263-Animals,
pubmed-meshheading:8602263-Antibodies, Helminth,
pubmed-meshheading:8602263-B-Lymphocytes,
pubmed-meshheading:8602263-Cell Line,
pubmed-meshheading:8602263-Cells, Cultured,
pubmed-meshheading:8602263-Cytokines,
pubmed-meshheading:8602263-Gene Targeting,
pubmed-meshheading:8602263-Histocompatibility Antigens Class II,
pubmed-meshheading:8602263-Immunoglobulin A,
pubmed-meshheading:8602263-Immunoglobulin Class Switching,
pubmed-meshheading:8602263-Immunoglobulin E,
pubmed-meshheading:8602263-Immunoglobulin G,
pubmed-meshheading:8602263-Interleukin-4,
pubmed-meshheading:8602263-Lymphocyte Activation,
pubmed-meshheading:8602263-Mice,
pubmed-meshheading:8602263-Nippostrongylus,
pubmed-meshheading:8602263-Receptors, IgE,
pubmed-meshheading:8602263-STAT6 Transcription Factor,
pubmed-meshheading:8602263-Signal Transduction,
pubmed-meshheading:8602263-Spleen,
pubmed-meshheading:8602263-T-Lymphocytes,
pubmed-meshheading:8602263-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:8602263-Trans-Activators
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pubmed:year |
1996
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pubmed:articleTitle |
Essential role of Stat6 in IL-4 signalling.
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pubmed:affiliation |
Institute for Molecular and Cellular Biology, Osaka University, Japan.
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pubmed:publicationType |
Journal Article
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