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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5254
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pubmed:dateCreated |
1996-4-17
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pubmed:abstractText |
A number of pathophysiologically relevant genes, including platelet-derived growth factor B-chain (PDGF-B), are induced in the vasculature after acute mechanical injury. In rat aorta, the activated expression of these genes was preceded by a marked increase in the amount of the early-growth-response gene product Egr-1 at the endothelial wound edge. Egr-1 interacts with a novel element in the proximal PDGF-B promoter, as well as with consensus elements in the promoters of other genes induced by endothelial injury. This interaction is crucial for injury-induced PDGF-B promoter-dependent expression. Sp1, whose binding site in the PDGF-B promoter overlaps that of Egr-1, occupies this element in unstimulated cells and is displaced by increasing amounts of Egr-1. These findings implicate Egr-1 in the up-regulated expression of PDGF-B and other potent mediators in mechanically injured arterial endothelial cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/EGR1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Early Growth Response Protein 1,
http://linkedlifedata.com/resource/pubmed/chemical/Egr1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Immediate-Early Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Platelet-Derived Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Sp1 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Tetradecanoylphorbol Acetate,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
271
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1427-31
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:8596917-Animals,
pubmed-meshheading:8596917-Aorta,
pubmed-meshheading:8596917-Base Sequence,
pubmed-meshheading:8596917-Binding Sites,
pubmed-meshheading:8596917-DNA-Binding Proteins,
pubmed-meshheading:8596917-Early Growth Response Protein 1,
pubmed-meshheading:8596917-Endothelium, Vascular,
pubmed-meshheading:8596917-Gene Expression Regulation,
pubmed-meshheading:8596917-Genes, Reporter,
pubmed-meshheading:8596917-Humans,
pubmed-meshheading:8596917-Immediate-Early Proteins,
pubmed-meshheading:8596917-Male,
pubmed-meshheading:8596917-Molecular Sequence Data,
pubmed-meshheading:8596917-Platelet-Derived Growth Factor,
pubmed-meshheading:8596917-Promoter Regions, Genetic,
pubmed-meshheading:8596917-Rats,
pubmed-meshheading:8596917-Rats, Sprague-Dawley,
pubmed-meshheading:8596917-Recombinant Proteins,
pubmed-meshheading:8596917-Sp1 Transcription Factor,
pubmed-meshheading:8596917-Tetradecanoylphorbol Acetate,
pubmed-meshheading:8596917-Transcription Factors,
pubmed-meshheading:8596917-Zinc Fingers
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pubmed:year |
1996
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pubmed:articleTitle |
Egr-1-induced endothelial gene expression: a common theme in vascular injury.
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pubmed:affiliation |
Vascular Research Division, Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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