| pubmed-article:8593167 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8593167 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:8593167 | lifeskim:mentions | umls-concept:C0147139 | lld:lifeskim |
| pubmed-article:8593167 | lifeskim:mentions | umls-concept:C0302600 | lld:lifeskim |
| pubmed-article:8593167 | lifeskim:mentions | umls-concept:C0178874 | lld:lifeskim |
| pubmed-article:8593167 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:8593167 | pubmed:dateCreated | 1996-4-1 | lld:pubmed |
| pubmed-article:8593167 | pubmed:abstractText | Thrombospondin (TSP-1) is a large glycoprotein secreted by platelets and synthesized by many cell types, including endothelial and tumor cells. Although controversy exists about the biological function of TSP-1, the following observations suggest that TSP-1 may potentiate tumor progression. (1) Tumor metastases in mice are promoted by TSP-1 and inhibited by anti-TSP-1 antibodies. (2) TSP-1 promotes tumor cell adhesion, migration and invasion. (3) TSP-1 promotes angiogenesis in the rat aorta model. (4) TSP-1 up-regulates the plasminogen activator system through a mechanism involving the activation of TGF-beta 1. (5) Human tumors express increased levels of the CSVTCG-specific TSP-1 receptor. (6) Tumor stroma is enriched in TSP-1. (7) Cancer patients have high blood levels of TSP-1. (8) Poor patient survival correlates with a higher expression of the CSVTCG-specific TSP-1 receptor on tumor cells. In this paper we discuss the evidence that TSP-1 promotes tumor progression and present a hypothetical scheme for its mechanism of action. | lld:pubmed |
| pubmed-article:8593167 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8593167 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8593167 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8593167 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8593167 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8593167 | pubmed:issn | 0265-9247 | lld:pubmed |
| pubmed-article:8593167 | pubmed:author | pubmed-author:TuszynskiG... | lld:pubmed |
| pubmed-article:8593167 | pubmed:author | pubmed-author:NicosiaR FRF | lld:pubmed |
| pubmed-article:8593167 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8593167 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:8593167 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8593167 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8593167 | pubmed:pagination | 71-6 | lld:pubmed |
| pubmed-article:8593167 | pubmed:dateRevised | 2005-11-16 | lld:pubmed |
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| pubmed-article:8593167 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8593167 | pubmed:articleTitle | The role of thrombospondin-1 in tumor progression and angiogenesis. | lld:pubmed |
| pubmed-article:8593167 | pubmed:affiliation | Department of Surgery, Medical College of Pennsylvania, Philadelphia, USA. | lld:pubmed |
| pubmed-article:8593167 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8593167 | pubmed:publicationType | Review | lld:pubmed |
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