Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1996-4-1
|
| pubmed:abstractText |
Thrombospondin (TSP-1) is a large glycoprotein secreted by platelets and synthesized by many cell types, including endothelial and tumor cells. Although controversy exists about the biological function of TSP-1, the following observations suggest that TSP-1 may potentiate tumor progression. (1) Tumor metastases in mice are promoted by TSP-1 and inhibited by anti-TSP-1 antibodies. (2) TSP-1 promotes tumor cell adhesion, migration and invasion. (3) TSP-1 promotes angiogenesis in the rat aorta model. (4) TSP-1 up-regulates the plasminogen activator system through a mechanism involving the activation of TGF-beta 1. (5) Human tumors express increased levels of the CSVTCG-specific TSP-1 receptor. (6) Tumor stroma is enriched in TSP-1. (7) Cancer patients have high blood levels of TSP-1. (8) Poor patient survival correlates with a higher expression of the CSVTCG-specific TSP-1 receptor on tumor cells. In this paper we discuss the evidence that TSP-1 promotes tumor progression and present a hypothetical scheme for its mechanism of action.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0265-9247
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
18
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
71-6
|
| pubmed:dateRevised |
2005-11-16
|
| pubmed:meshHeading |
pubmed-meshheading:8593167-Amino Acid Sequence,
pubmed-meshheading:8593167-Animals,
pubmed-meshheading:8593167-Antigens, CD36,
pubmed-meshheading:8593167-Aorta,
pubmed-meshheading:8593167-Cell Adhesion,
pubmed-meshheading:8593167-Cornea,
pubmed-meshheading:8593167-Disease Progression,
pubmed-meshheading:8593167-Endothelium, Vascular,
pubmed-meshheading:8593167-Humans,
pubmed-meshheading:8593167-Membrane Glycoproteins,
pubmed-meshheading:8593167-Mice,
pubmed-meshheading:8593167-Models, Biological,
pubmed-meshheading:8593167-Molecular Sequence Data,
pubmed-meshheading:8593167-Neoplasm Invasiveness,
pubmed-meshheading:8593167-Neoplasm Proteins,
pubmed-meshheading:8593167-Neoplasms,
pubmed-meshheading:8593167-Neoplasms, Experimental,
pubmed-meshheading:8593167-Neovascularization, Pathologic,
pubmed-meshheading:8593167-Neovascularization, Physiologic,
pubmed-meshheading:8593167-Rabbits,
pubmed-meshheading:8593167-Rats,
pubmed-meshheading:8593167-Thrombospondins
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
The role of thrombospondin-1 in tumor progression and angiogenesis.
|
| pubmed:affiliation |
Department of Surgery, Medical College of Pennsylvania, Philadelphia, USA.
|
| pubmed:publicationType |
Journal Article,
Review
|