Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1996-3-25
pubmed:abstractText
Intraoperative mitomycin-C application has been well accepted recently as a useful adjunctive procedure to enhance the filtering effect in glaucoma surgery. However, the exact dose of mitomycin-C left after such a procedure in the ocular tissue is variable and unclear. It is important to determine such residual because of potential long-term toxicity of mitomycin-C to the eye. Based on previous successful experience using preoperative mitomycin-C subconjunctival injection in the THC-YAG laser sclerostomy on rabbits, the effect of intraocular pressure (IOP) control and its clinical observation was studied in six eyes of six refractory and high risk glaucoma patients by subconjunctival 1.2 micrograms to 3.6 micrograms mitomycin-C injection 24 to 72 hours prior to classic, routine, limbal-based trabeculectomy surgery. After 18 months of satisfactory clinical observation of the first eye for IOP, functioning bleb appearance and smooth clinical course, the same procedure was used on an additional five eyes, with a follow-up period of more than five months. Average IOP was reduced from 27.8 mm Hg (range 24 to 34 mm Hg) preoperatively to 9.5 mm Hg (range 5 to 14 mm Hg) postoperatively, with a smooth clinical course. The advantages of such preoperative subconjunctival mitomycin-C injection are emphasized here.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1080-7683
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
233-41
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:8590255-Adolescent, pubmed-meshheading:8590255-Adult, pubmed-meshheading:8590255-Animals, pubmed-meshheading:8590255-Antibiotics, Antineoplastic, pubmed-meshheading:8590255-Chemotherapy, Adjuvant, pubmed-meshheading:8590255-Child, pubmed-meshheading:8590255-Conjunctiva, pubmed-meshheading:8590255-Female, pubmed-meshheading:8590255-Glaucoma, pubmed-meshheading:8590255-Humans, pubmed-meshheading:8590255-Injections, pubmed-meshheading:8590255-Intraocular Pressure, pubmed-meshheading:8590255-Male, pubmed-meshheading:8590255-Middle Aged, pubmed-meshheading:8590255-Mitomycin, pubmed-meshheading:8590255-Pilot Projects, pubmed-meshheading:8590255-Premedication, pubmed-meshheading:8590255-Rabbits, pubmed-meshheading:8590255-Trabeculectomy, pubmed-meshheading:8590255-Visual Acuity, pubmed-meshheading:8590255-Visual Fields
pubmed:year
1995
pubmed:articleTitle
Preoperative mitomycin-C subconjunctival injection and glaucoma filtering surgery.
pubmed:affiliation
Department of Ophthalmology, National Taiwan University, Taipei, Republic of China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't