Linked Life Data

8590170

Source:http://linkedlifedata.com/resource/pubmed/id/8590170

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1996-3-27
pubmed:abstractText
A method for identification of eukaryotic promoters by localization of binding sites for transcription factors has been suggested. The binding sites for a range of transcription factors have been found to be distributed unevenly. Based on these distributions, we have constructed a weight matrix of binding site localization. On the basis of the weight matrix we have, in turn, designed an algorithm for promoter recognition. To increase the accuracy of the method, we have developed a routine that breaks any promoter sample into subsamples. The method to be reported on allows much better recognition accuracy than does the approach based on detection of the TATA box. In particular, the overprediction error is three times lower following our method. The program FunSiteP recognizes promoters from newly uncovered sequences and tentatively identifies the functional class the promoters must belong to. We have introduced the notion of 'regulatory potential' for the degree to which any region of the sequences is similar to the real eukaryotic promoter. By making use of the potential, we have revealed putative transcription start sites and extended regions of transcription regulation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0266-7061
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
477-88
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Eukaryotic promoter recognition by binding sites for transcription factors.
pubmed:affiliation
Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't