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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1996-3-27
|
| pubmed:abstractText |
We assessed the effect of an ascending-dose regimen on the development of tolerance to the anticonvulsant and ataxic effects of pentobarbital in four groups of amygdala-kindled rats. Each rat received 20 bidaily (one every 48 h) trials in which an intraperitoneal (IP) pentobarbital or vehicle injection was delivered 1 h before a convulsive amygdala stimulation. On each trial, the rats in the three pentobarbital groups received either a high dose (50 mg/kg), a low dose (10mg/kg), or ascending doses of pentobarbital that began at 10 mg/kg and increased to as high as 26 mg/kg by 1 mg/kg increments as tolerance developed to its anticonvulsant effect; the rats in the vehicle group received saline. The rats in the ascending-dose condition displayed significantly more tolerance to the anticonvulsant effect of pentobarbital than did the other rats; in contrast, the high-dose rats displayed more tolerance to the ataxic effect of pentobarbital than did the other rats. These findings extend previous reports of the facilitatory effect of ascending-dose regimens on the development of tolerance to the anticonvulsant effect of benzodiazepines, and show that the facilitatory effect of ascending-dose regimens does not extend to all drug effects.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0091-3057
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
52
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
825-9
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8587926-Animals,
pubmed-meshheading:8587926-Anticonvulsants,
pubmed-meshheading:8587926-Ataxia,
pubmed-meshheading:8587926-Dose-Response Relationship, Drug,
pubmed-meshheading:8587926-Drug Tolerance,
pubmed-meshheading:8587926-Kindling, Neurologic,
pubmed-meshheading:8587926-Male,
pubmed-meshheading:8587926-Pentobarbital,
pubmed-meshheading:8587926-Rats
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Tolerance to the anticonvulsant and ataxic effects of pentobarbital: effect of an ascending-dose regimen.
|
| pubmed:affiliation |
Department of Anatomy, University of British Columbia, Vancouver, Canada.
|
| pubmed:publicationType |
Journal Article
|