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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1996-3-27
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pubmed:abstractText |
Dibasic esters (DBE) are a mixture of 3 carboxylic acid esters which are used in the paint and coatings industry. In this study, groups of pregnant Crl:CD BR rats were exposed to either 0.16, 0.4, or 1.0 mg DBE/L by inhalation for 6 hr/day from Days 7 through 16 of gestation (day in which copulation plug was detected was designated Day 1G). A control group of chambered pregnant rats was exposed simultaneously to air only. All female rats were euthanized on Day 21G and the fetuses were examined. A suppression of both food consumption and the rate of body weight gain was seen in the 0.4 and 1.0 mg/L groups during the first 6 exposure days. Staining on the fur and perineal area was seen in rats exposed to 1.0 mg/L and liver weight decreases, although not statistically significant, occurred in the 2 high exposure groups. None of the reproductive parameters were altered in any of the groups and no fetal effects were detected. DBE is not a developmental toxin in the rat following inhalation exposures as high as 1.0 mg DBE/L during the period of organogenesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0148-0545
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
295-314
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:8586022-Abnormalities, Drug-Induced,
pubmed-meshheading:8586022-Adipic Acids,
pubmed-meshheading:8586022-Administration, Inhalation,
pubmed-meshheading:8586022-Animals,
pubmed-meshheading:8586022-Body Weight,
pubmed-meshheading:8586022-Dicarboxylic Acids,
pubmed-meshheading:8586022-Embryonic and Fetal Development,
pubmed-meshheading:8586022-Female,
pubmed-meshheading:8586022-Gestational Age,
pubmed-meshheading:8586022-Glutarates,
pubmed-meshheading:8586022-Liver,
pubmed-meshheading:8586022-Organ Size,
pubmed-meshheading:8586022-Ovary,
pubmed-meshheading:8586022-Pregnancy,
pubmed-meshheading:8586022-Prenatal Exposure Delayed Effects,
pubmed-meshheading:8586022-Rats,
pubmed-meshheading:8586022-Rats, Sprague-Dawley,
pubmed-meshheading:8586022-Reproduction,
pubmed-meshheading:8586022-Succinates
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pubmed:year |
1995
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pubmed:articleTitle |
Developmental toxicity of dibasic esters by inhalation in the rat.
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pubmed:affiliation |
E.I. DuPont de Nemours and Company, Haskell Laboratory for Toxicology and Industrial Medicine, Newark, DE 19714, USA.
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pubmed:publicationType |
Journal Article
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