Linked Life Data

8577791

Source:http://linkedlifedata.com/resource/pubmed/id/8577791

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1996-3-11
pubmed:abstractText
7-hydroxy-N,N-di-n-propyl-2-aminotetralin (7-OH-DPAT) injected bilaterally in the nucleus accumbens (NAC) resulted in profound, noncatatonic, dose-dependent (0.3-3 mg total dose) hypolocomotion but without inducing yawning. It also decreased intake of a highly preferred 3% sucrose solution (1 microgram total dose). Systemic injection of 7-OH-DPAT (0.1-3.0 mg/kg, i.p.) similarly induced hypolocomotion while failing to induce yawning. In none of these studies did rats show any signs of hyperlocomotion or any stereotyped responses normally associated with D2 or mixed D1/D2 receptor stimulation. These data suggest that hypolocomotion elicited by 7-OH-DPAT in the NAC may be mediated at the D3 receptor as distinct from the D2 dopamine receptor. We discuss the possibility that the behavioural effects we observed are mediated at D3 autoreceptors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0091-3057
pubmed:author
pubmed:issnType
Print
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
275-80
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
7-OH-DPAT injected into the accumbens reduces locomotion and sucrose ingestion: D3 autoreceptor-mediated effects?
pubmed:affiliation
Division of Psychology, School of Health and Human Sciences, University of Hertfordshire, Hatfield, United Kingdom.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't