Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-2
|
pubmed:dateCreated |
1996-3-8
|
pubmed:abstractText |
5'-end maturation of messenger RNAs via acquisition of a trans-spliced leader sequence occurs in several primitive eukaryotes, some of which are parasitic. This type of trans-splicing proceeds though a two-step reaction pathway directly analogous to that of cis-splicing and like cis-splicing it requires multiple U snRNP cofactors. This minireview attempts to provide a brief synopsis of our current understanding of the evolution and biological significance of trans-splicing. Progress in deciphering the mechanism of trans-splicing, particularly as it relates to current models of cis-splicing, is also discussed.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jul
|
pubmed:issn |
0166-6851
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
73
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1-6
|
pubmed:dateRevised |
2010-11-18
|
pubmed:meshHeading |
pubmed-meshheading:8577317-Animals,
pubmed-meshheading:8577317-Biological Evolution,
pubmed-meshheading:8577317-Caenorhabditis elegans,
pubmed-meshheading:8577317-Phylogeny,
pubmed-meshheading:8577317-RNA, Helminth,
pubmed-meshheading:8577317-RNA, Protozoan,
pubmed-meshheading:8577317-RNA Precursors,
pubmed-meshheading:8577317-RNA Splicing,
pubmed-meshheading:8577317-Ribonucleoproteins, Small Nuclear,
pubmed-meshheading:8577317-Trypanosoma brucei brucei
|
pubmed:year |
1995
|
pubmed:articleTitle |
trans-splicing: an update.
|
pubmed:affiliation |
Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
|
pubmed:publicationType |
Journal Article,
Review
|