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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1996-3-13
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pubmed:abstractText |
The role of angiotensin-converting enzyme (ACE) inhibition with ramipril on mesenteric vascular hypertrophy and urinary albumin excretion was explored in a normotensive model of experimental diabetes. Serial measurements of albuminuria were performed in Sprague-Dawley control, diabetic rats, and diabetic rats treated with ramipril. Over 24 weeks, urinary albumin excretion showed a continuous rise in the untreated diabetic rats. Ramipril prevented the increase in albuminuria over the whole study period. After 6 months, animals were perfused with glutaraldehyde and sacrificed for measurement of mesenteric vessel wall/lumen ratio and kidney weight. Diabetes was associated with increased mesenteric wall/lumen ratio and kidney weight. ACE inhibition, despite no effect on glycemic control, attenuated mesenteric vascular hypertrophy but did not decrease kidney weight. In addition to the well-described renoprotective effects of ACE inhibition in diabetes, this class of agents may have a favorable effect on diabetic vascular disease.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1056-8727
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
318-22
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8573756-Albuminuria,
pubmed-meshheading:8573756-Angiotensin-Converting Enzyme Inhibitors,
pubmed-meshheading:8573756-Animals,
pubmed-meshheading:8573756-Blood Glucose,
pubmed-meshheading:8573756-Body Weight,
pubmed-meshheading:8573756-Diabetes Mellitus, Experimental,
pubmed-meshheading:8573756-Diabetic Nephropathies,
pubmed-meshheading:8573756-Hemoglobin A, Glycosylated,
pubmed-meshheading:8573756-Hypertrophy,
pubmed-meshheading:8573756-Kidney,
pubmed-meshheading:8573756-Male,
pubmed-meshheading:8573756-Muscle, Smooth, Vascular,
pubmed-meshheading:8573756-Organ Size,
pubmed-meshheading:8573756-Ramipril,
pubmed-meshheading:8573756-Rats,
pubmed-meshheading:8573756-Rats, Sprague-Dawley,
pubmed-meshheading:8573756-Reference Values,
pubmed-meshheading:8573756-Renin,
pubmed-meshheading:8573756-Splanchnic Circulation,
pubmed-meshheading:8573756-Systole
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pubmed:articleTitle |
Diabetic vascular hypertrophy and albuminuria: effect of angiotensin converting enzyme inhibition.
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pubmed:affiliation |
Department of Medicine, University of Melbourne, Austin, Australia.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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