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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
1996-3-5
|
| pubmed:abstractText |
We have investigated the induction and role of natural killer (NK) activity in lymphocytic choriomeningitis virus (LCMV)-infected beta 2-microglobulin-deficient (beta 2m-) mice. We demonstrate that LCMV infection is more effective than polyinosinic:polycytidylic acid (poly I:C) at stimulating NK activity in beta 2m- mice. In addition, beta 2m- NK cells respond poorly to in vitro treatment with IL-12. The target specificity of the virally induced NK cells is similar to that previously reported for chemically induced beta 2m- NK cells. In both cases they can lyse YAC-1 tumor cells but are unable to kill beta 2m- or beta 2m+ T cell blasts. We have also found that the time course of induction of NK and cytotoxic T lymphocyte (CTL) activity by LCMV in beta 2m- mice is delayed compared with normal mice. Maximal NK and CTL activity is attained at day 8 and 10 post-infection respectively in beta 2m- mice compared with day 4 and 6-8 in B6 mice. Whereas normal mice die approximately 7 days following intracranial infection with LCMV, the course of disease in beta 2m- mice is protracted and characterized by a marked loss of body weight. We show that although the CD4+ CTL response in these mice is intimately involved in mediating weight loss, the virus-induced NK cells do not appear to play a role in the disease.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0953-8178
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
7
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1545-56
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8562499-Animals,
pubmed-meshheading:8562499-CD4-Positive T-Lymphocytes,
pubmed-meshheading:8562499-Cytotoxicity, Immunologic,
pubmed-meshheading:8562499-Disease Progression,
pubmed-meshheading:8562499-Female,
pubmed-meshheading:8562499-H-2 Antigens,
pubmed-meshheading:8562499-Humans,
pubmed-meshheading:8562499-Interleukin-12,
pubmed-meshheading:8562499-Killer Cells, Natural,
pubmed-meshheading:8562499-Lymphocyte Depletion,
pubmed-meshheading:8562499-Lymphocytic Choriomeningitis,
pubmed-meshheading:8562499-Male,
pubmed-meshheading:8562499-Mice,
pubmed-meshheading:8562499-Mice, Inbred C57BL,
pubmed-meshheading:8562499-Mice, Mutant Strains,
pubmed-meshheading:8562499-Poly I-C,
pubmed-meshheading:8562499-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:8562499-Weight Loss,
pubmed-meshheading:8562499-beta 2-Microglobulin
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Natural killer cell activity in lymphocytic choriomeningitis virus-infected beta 2-microglobulin-deficient mice.
|
| pubmed:affiliation |
Department of Microbiology and Immunology, University of North Carolina, Chapel Hill 27599-7290, USA.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|