Linked Life Data

8561799

Source:http://linkedlifedata.com/resource/pubmed/id/8561799

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1996-2-23
pubmed:abstractText
In the course of studying the role of hsp70 in the differentiation of pancreatic beta cells, transgenic founder mice were generated with the human hsp70 gene fused to the human insulin gene promoter. One resulted in a transgenic line that consistently developed diabetes mellitus, but unexpectedly three other independent transgenic founders developed generalized malignant lymphoma within 10 months after birth. Immunochemical and RT-PCR analyses revealed that the transgene was expressed in the lymphoma cells. Flow cytometric analyses revealed that the tumor was originated from T lymphocytes. Our results provide the first experimental evidence that hsp70 is involved in the tumorigenesis of T cells most likely through the blockage of apoptotic signals.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0006-291X
pubmed:author
pubmed:issnType
Print
pubmed:day
17
pubmed:volume
218
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
582-7
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1996
pubmed:articleTitle
T cell lymphoma in transgenic mice expressing the human Hsp70 gene.
pubmed:affiliation
Transgenic Mice Center, Cancer Research Institute, Seoul, Korea.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't