Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1996-2-14
|
| pubmed:abstractText |
It has been established that oligoclonal expansion is a common feature of the CD8+ T cell population, particularly within the CD8+ CD57+ lymphocyte subset. In addition, clonal malignancies involving CD8+ CD57+ T cells (large granulocytic lymphocytic leukemias) are often accompanied by rheumatoid arthritis, Felty's syndrome, or both. Therefore, to identify disease-related alterations in the CD8+ T cell repertoire, we have compared the patterns of oligoclonality in the CD8+ T cells of rheumatoid arthritis patients (n = 32) with those of age-matched controls (n = 25). By using a multiplex PCR assay for the CDR3 length of TCR beta-chains, we have found a striking increase in the frequency of CD8+ oligoclonality involving V beta 3 TCR: 50% of the rheumatoid arthritis patients had evidence of oligoclonality in this TCR family compared with 4% of controls (p < 0.0002). In addition, two unrelated RA patients had clonally dominant CD8+ T cell beta receptors that were identical in amino acid sequence, suggesting selection by a common Ag. An analysis of a subset of RA patients with mAbs specific for V beta 3 TCR revealed the presence of clonal expansion in a minority of patients usually, but not exclusively, involving the CD57+ subset. These data define a phenotype of the T cell repertoire that is strongly associated with rheumatoid arthritis; the mechanisms and genetic and environmental factors that explain this phenomenon remain to be defined.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0022-1767
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
156
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
852-8
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8543842-Adult,
pubmed-meshheading:8543842-Aged,
pubmed-meshheading:8543842-Aged, 80 and over,
pubmed-meshheading:8543842-Amino Acid Sequence,
pubmed-meshheading:8543842-Antigens, CD57,
pubmed-meshheading:8543842-Arthritis, Rheumatoid,
pubmed-meshheading:8543842-Base Sequence,
pubmed-meshheading:8543842-Cell Lineage,
pubmed-meshheading:8543842-Clone Cells,
pubmed-meshheading:8543842-Female,
pubmed-meshheading:8543842-Gene Rearrangement, beta-Chain T-Cell Antigen Receptor,
pubmed-meshheading:8543842-HLA Antigens,
pubmed-meshheading:8543842-Humans,
pubmed-meshheading:8543842-Immunophenotyping,
pubmed-meshheading:8543842-Male,
pubmed-meshheading:8543842-Middle Aged,
pubmed-meshheading:8543842-Molecular Sequence Data,
pubmed-meshheading:8543842-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:8543842-T-Lymphocytes, Cytotoxic
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Oligoclonality of V beta 3 TCR chains in the CD8+ T cell population of rheumatoid arthritis patients.
|
| pubmed:affiliation |
Department of Medicine, North Shore University Hospital-Cornell University Medical College, Manhasset, NY 11030, USA.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|