| pubmed-article:8543805 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8543805 | lifeskim:mentions | umls-concept:C1706586 | lld:lifeskim |
| pubmed-article:8543805 | lifeskim:mentions | umls-concept:C1155065 | lld:lifeskim |
| pubmed-article:8543805 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:8543805 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8543805 | lifeskim:mentions | umls-concept:C0033713 | lld:lifeskim |
| pubmed-article:8543805 | lifeskim:mentions | umls-concept:C0812215 | lld:lifeskim |
| pubmed-article:8543805 | lifeskim:mentions | umls-concept:C2746015 | lld:lifeskim |
| pubmed-article:8543805 | lifeskim:mentions | umls-concept:C1155437 | lld:lifeskim |
| pubmed-article:8543805 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:8543805 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:8543805 | lifeskim:mentions | umls-concept:C0332291 | lld:lifeskim |
| pubmed-article:8543805 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8543805 | pubmed:dateCreated | 1996-2-14 | lld:pubmed |
| pubmed-article:8543805 | pubmed:abstractText | We have studied pim-1 proto-oncogene expression in human T cell responses to Ag receptor-generated signals. The pim-1 gene encodes a serine/threonine protein kinase that is expressed primarily in cells of hematopoietic lineage and is implicated in the intracellular signaling processes accompanying lymphocyte activation. We show here that pim-1 mRNA expression is rapidly induced after receptor cross-linking with anti-CD3 Abs. We examined the linkage of pim-1 expression to known signaling pathways generated through the T cell Ag receptor. pim-1 mRNA was not substantially induced after elevation of intracellular free Ca2+. In contrast, PMA, which directly activates PKC, induced rapid pim-1 expression. Further, anti-CD3- or PMA-induced pim-1 expression was markedly reduced by various PKC inhibitors and by deficiency of the PKC epsilon isoform in a mutant T cell line. Thus, T cell Ag receptor-linked pim-1 expression appears to be coupled to the PKC component of transmembrane signaling. Because the activation of protein kinase C has been shown to activate Raf-1 kinase activity, the involvement of Raf-1 in pim-1 expression was also investigated using a human T cell line stably transfected with an inducible Raf expression vector. Although the overexpression of activated Raf was shown to cause a substantial increase in IL-2 expression, no discernible effects on pim-1 were apparent. In addition, we examined transcriptional and post-transcriptional mechanisms involved in PKC-mediated pim-1 expression and observed that both transcriptional and post-transcriptional mechanisms are coordinately involved in the up-regulation of the pim-1 proto-oncogene. | lld:pubmed |
| pubmed-article:8543805 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8543805 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8543805 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8543805 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8543805 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:8543805 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8543805 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8543805 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8543805 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8543805 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8543805 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8543805 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8543805 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8543805 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8543805 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8543805 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8543805 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8543805 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8543805 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8543805 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8543805 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:8543805 | pubmed:author | pubmed-author:LongAA | lld:pubmed |
| pubmed-article:8543805 | pubmed:author | pubmed-author:WingettDD | lld:pubmed |
| pubmed-article:8543805 | pubmed:author | pubmed-author:MagnusonN SNS | lld:pubmed |
| pubmed-article:8543805 | pubmed:author | pubmed-author:KelleherDD | lld:pubmed |
| pubmed-article:8543805 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8543805 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:8543805 | pubmed:volume | 156 | lld:pubmed |
| pubmed-article:8543805 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8543805 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8543805 | pubmed:pagination | 549-57 | lld:pubmed |
| pubmed-article:8543805 | pubmed:dateRevised | 2010-8-25 | lld:pubmed |
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| pubmed-article:8543805 | pubmed:meshHeading | pubmed-meshheading:8543805-... | lld:pubmed |
| pubmed-article:8543805 | pubmed:year | 1996 | lld:pubmed |
| pubmed-article:8543805 | pubmed:articleTitle | pim-1 proto-oncogene expression in anti-CD3-mediated T cell activation is associated with protein kinase C activation and is independent of Raf-1. | lld:pubmed |
| pubmed-article:8543805 | pubmed:affiliation | Department of Veterans Affairs, Boise, ID 83702, USA. | lld:pubmed |
| pubmed-article:8543805 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8543805 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8543805 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:8543805 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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