| pubmed-article:8537916 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8537916 | lifeskim:mentions | umls-concept:C0001554 | lld:lifeskim |
| pubmed-article:8537916 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:8537916 | lifeskim:mentions | umls-concept:C0021753 | lld:lifeskim |
| pubmed-article:8537916 | lifeskim:mentions | umls-concept:C0005974 | lld:lifeskim |
| pubmed-article:8537916 | lifeskim:mentions | umls-concept:C0074529 | lld:lifeskim |
| pubmed-article:8537916 | lifeskim:mentions | umls-concept:C1440080 | lld:lifeskim |
| pubmed-article:8537916 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:8537916 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:8537916 | pubmed:dateCreated | 1996-2-8 | lld:pubmed |
| pubmed-article:8537916 | pubmed:abstractText | The effects of recombinant human interleukin-1 beta (rhIL-1 beta) on alveolar bone resorptive activity in rats were examined. Continuous administration of rhIL-1 beta or phosphate-buffered saline (PBS) was given via osmotic pumps for 3, 7 and 14 days to rats with silk ligatures around second maxillary molars. Other animals without ligatures received insertion of pumps containing rhIL-1 beta or remained untreated. Sections were subject to three different stains:--hematoxylin and eosin (H-E) for histology, acid phosphatase (ACPase) activity for osteoclast detection, and immunohistochemistry using anti-rat monocyte/macrophage monoclonal antibody (ED 1). In addition, body weight, plasma calcium and phosphorus levels were monitored. The mean body weight of rats receiving rhIL-1 beta was significantly lower (P < 0.05 to P < 0.01) compared with untreated rats throughout the experimental period. On Day 7, plasma calcium and phosphorus levels were significantly lower in rats receiving rhIL-1 beta than in rats receiving PBS only (P < 0.05). Sections revealed a moderate inflammatory cell infiltrate reaching near the alveolar crest in both groups with ligatures on Day 3. Only rats receiving rhIL-1 beta exhibited enhancement of inflammatory cell invasion on Days 7 and 14. In rats receiving rhIL-1 beta with ligatures, numerous resorption lacunae containing ACPase-positive multinucleated giant cells (MNGCs), coinciding with ED1-positive cells, were located on the mesial side of the septum where extensive bone resorption had occurred throughout the experimental period. In animals receiving rhIL-1 beta without ligatures, compared with untreated rats, increased ACPase-positive cells were observed on the mesial side of the septum on Day 3. In animals receiving PBS only, a few ACPase-positive cells were observed confined to the mesial regions where slight bone resorption occurred on Days 7 and 14. These results indicate that the administration of rhIL-1 beta accelerated alveolar bone destruction in ligature-induced periodontal tissue inflammation over a two-week period. | lld:pubmed |
| pubmed-article:8537916 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8537916 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8537916 | pubmed:citationSubset | D | lld:pubmed |
| pubmed-article:8537916 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8537916 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8537916 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:8537916 | pubmed:issn | 0904-2512 | lld:pubmed |
| pubmed-article:8537916 | pubmed:author | pubmed-author:SuzukiTT | lld:pubmed |
| pubmed-article:8537916 | pubmed:author | pubmed-author:OnoYY | lld:pubmed |
| pubmed-article:8537916 | pubmed:author | pubmed-author:HaraKK | lld:pubmed |
| pubmed-article:8537916 | pubmed:author | pubmed-author:TakaiMM | lld:pubmed |
| pubmed-article:8537916 | pubmed:author | pubmed-author:TaniguchiYY | lld:pubmed |
| pubmed-article:8537916 | pubmed:author | pubmed-author:SaitohSS | lld:pubmed |
| pubmed-article:8537916 | pubmed:author | pubmed-author:YoshieHH | lld:pubmed |
| pubmed-article:8537916 | pubmed:author | pubmed-author:KoideMM | lld:pubmed |
| pubmed-article:8537916 | pubmed:author | pubmed-author:SudaSS | lld:pubmed |
| pubmed-article:8537916 | pubmed:author | pubmed-author:OfujiYY | lld:pubmed |
| pubmed-article:8537916 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8537916 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:8537916 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8537916 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8537916 | pubmed:pagination | 420-34 | lld:pubmed |
| pubmed-article:8537916 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
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| pubmed-article:8537916 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:8537916 | pubmed:articleTitle | In vivo administration of IL-1 beta accelerates silk ligature-induced alveolar bone resorption in rats. | lld:pubmed |
| pubmed-article:8537916 | pubmed:affiliation | Department of Periodontology, Niigata University School of Dentistry, Japan. | lld:pubmed |
| pubmed-article:8537916 | pubmed:publicationType | Journal Article | lld:pubmed |
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