Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
1996-2-8
|
| pubmed:abstractText |
The effects of recombinant human interleukin-1 beta (rhIL-1 beta) on alveolar bone resorptive activity in rats were examined. Continuous administration of rhIL-1 beta or phosphate-buffered saline (PBS) was given via osmotic pumps for 3, 7 and 14 days to rats with silk ligatures around second maxillary molars. Other animals without ligatures received insertion of pumps containing rhIL-1 beta or remained untreated. Sections were subject to three different stains:--hematoxylin and eosin (H-E) for histology, acid phosphatase (ACPase) activity for osteoclast detection, and immunohistochemistry using anti-rat monocyte/macrophage monoclonal antibody (ED 1). In addition, body weight, plasma calcium and phosphorus levels were monitored. The mean body weight of rats receiving rhIL-1 beta was significantly lower (P < 0.05 to P < 0.01) compared with untreated rats throughout the experimental period. On Day 7, plasma calcium and phosphorus levels were significantly lower in rats receiving rhIL-1 beta than in rats receiving PBS only (P < 0.05). Sections revealed a moderate inflammatory cell infiltrate reaching near the alveolar crest in both groups with ligatures on Day 3. Only rats receiving rhIL-1 beta exhibited enhancement of inflammatory cell invasion on Days 7 and 14. In rats receiving rhIL-1 beta with ligatures, numerous resorption lacunae containing ACPase-positive multinucleated giant cells (MNGCs), coinciding with ED1-positive cells, were located on the mesial side of the septum where extensive bone resorption had occurred throughout the experimental period. In animals receiving rhIL-1 beta without ligatures, compared with untreated rats, increased ACPase-positive cells were observed on the mesial side of the septum on Day 3. In animals receiving PBS only, a few ACPase-positive cells were observed confined to the mesial regions where slight bone resorption occurred on Days 7 and 14. These results indicate that the administration of rhIL-1 beta accelerated alveolar bone destruction in ligature-induced periodontal tissue inflammation over a two-week period.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
D
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acid Phosphatase,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Coloring Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Insect Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphorus,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Silk
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0904-2512
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
24
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
420-34
|
| pubmed:dateRevised |
2005-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8537916-Acid Phosphatase,
pubmed-meshheading:8537916-Alveolar Bone Loss,
pubmed-meshheading:8537916-Animals,
pubmed-meshheading:8537916-Antibodies, Monoclonal,
pubmed-meshheading:8537916-Body Weight,
pubmed-meshheading:8537916-Bone Resorption,
pubmed-meshheading:8537916-Calcium,
pubmed-meshheading:8537916-Coloring Agents,
pubmed-meshheading:8537916-Giant Cells,
pubmed-meshheading:8537916-Humans,
pubmed-meshheading:8537916-Immunohistochemistry,
pubmed-meshheading:8537916-Infusion Pumps,
pubmed-meshheading:8537916-Insect Proteins,
pubmed-meshheading:8537916-Interleukin-1,
pubmed-meshheading:8537916-Ligation,
pubmed-meshheading:8537916-Macrophages,
pubmed-meshheading:8537916-Male,
pubmed-meshheading:8537916-Maxillary Diseases,
pubmed-meshheading:8537916-Molar,
pubmed-meshheading:8537916-Monocytes,
pubmed-meshheading:8537916-Osteoclasts,
pubmed-meshheading:8537916-Periodontitis,
pubmed-meshheading:8537916-Phosphorus,
pubmed-meshheading:8537916-Proteins,
pubmed-meshheading:8537916-Rats,
pubmed-meshheading:8537916-Rats, Wistar,
pubmed-meshheading:8537916-Recombinant Proteins,
pubmed-meshheading:8537916-Silk,
pubmed-meshheading:8537916-Sutures
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
In vivo administration of IL-1 beta accelerates silk ligature-induced alveolar bone resorption in rats.
|
| pubmed:affiliation |
Department of Periodontology, Niigata University School of Dentistry, Japan.
|
| pubmed:publicationType |
Journal Article
|