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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
|
| pubmed:dateCreated |
1996-2-7
|
| pubmed:databankReference | |
| pubmed:abstractText |
Ly9 is a mouse cell membrane antigen found on all lymphocytes and coded for by a gene that maps to chromosome 1. We previously described the isolation and characterization of a full-length cDNA clone for mouse Ly9. Using cross-species hybridization we isolated cDNA clones encoding the human homologue Humly9. Analysis of the predicted protein sequence suggests that the extra-cellular portion of the Humly9 molecules is composed of four Ig-like domains: a V domain (V) without disulphide bonds and a truncated C2 domain (tC2) with two disulphide bonds, a second V domain without disulphide bonds and a second tC2 with two disulphide bonds, i.e., as V-tC2-V-tC2. The gene encoding Humly9 was mapped to chromosome 1 by analysis of human/hamster hybrids, and more specifically to the 1q22 region by in situ hybridization. The protein sequence data support the view that Humly9 belongs to the immunoglobulin-superfamily subgroup which includes CD48, CD2, and LFA-3.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0093-7711
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
43
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
13-9
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8537117-Amino Acid Sequence,
pubmed-meshheading:8537117-Animals,
pubmed-meshheading:8537117-Antigens, Ly,
pubmed-meshheading:8537117-Base Sequence,
pubmed-meshheading:8537117-Chromosome Mapping,
pubmed-meshheading:8537117-Chromosomes, Human, Pair 1,
pubmed-meshheading:8537117-Cricetinae,
pubmed-meshheading:8537117-DNA, Complementary,
pubmed-meshheading:8537117-Gene Library,
pubmed-meshheading:8537117-Genes,
pubmed-meshheading:8537117-Humans,
pubmed-meshheading:8537117-Hybrid Cells,
pubmed-meshheading:8537117-In Situ Hybridization, Fluorescence,
pubmed-meshheading:8537117-Mice,
pubmed-meshheading:8537117-Molecular Sequence Data,
pubmed-meshheading:8537117-Multigene Family,
pubmed-meshheading:8537117-Sequence Alignment,
pubmed-meshheading:8537117-Sequence Homology, Amino Acid,
pubmed-meshheading:8537117-Species Specificity
|
| pubmed:year |
1996
|
| pubmed:articleTitle |
Isolation and characterization of cDNA clones for Humly9: the human homologue of mouse Ly9.
|
| pubmed:affiliation |
Molecular Immunogenetics Laboratory, Austin Research Institute, Austin Hospital, Heidelberg, Vic, Australia.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|