Linked Life Data

8534713

Source:http://linkedlifedata.com/resource/pubmed/id/8534713

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1996-2-2
pubmed:abstractText
Heparin, routinely used in peritoneal dialysis, has been found to have various effects, mainly inhibitory. Its infusion into the peritoneal cavity may adversely affect mesothelial cell growth and regeneration. Thus we wished to determine if heparin inhibits mesothelial cell growth and is does-dependent. Rat mesothelial cells were incubated for 3 days and 6 days with 200, 100, 20, 2, and 0.5 U/mL of heparin. Cellular proliferation and protein synthesis were determined by liquid scintillation counting after 24-hour pulses with 3H-thymidine and 3H-leucine. Heparin at 2 and 0.5 U/mL had no significant effect on radionuclide uptake. At 100 U/mL heparin inhibited radionuclide uptake by at least 50%. These findings indicate that heparin in small concentrations may be harmless, but at higher concentrations is inhibitory to mesothelial cell growth and proliferation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1197-8554
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
239-42
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Inhibition of mesothelial cell growth and protein synthesis by heparin.
pubmed:affiliation
Kidney Center, Kitasato University Hospital, Kanagawa, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't