Linked Life Data

8532710

Source:http://linkedlifedata.com/resource/pubmed/id/8532710

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1996-1-30
pubmed:abstractText
The high affinity receptor of phorbol-ester and related tumor promoters is the isozyme family protein kinase C (PKC). Activation of PKC by the phorbol esters is a pivotal event in phorbol ester-mediated tumor promotion. PKC activation is also implicated in tumor promotion of colonic epithelial cells by endogenous and dietary factors such as bile acids, free fatty acids, and diacylglycerols, suggesting that suppression of the inappropriate activation of colonic epithelial PKC by these factors could be an effective strategy of chemoprevention. Phorbol-ester tumor promoters induce pleiotropic resistance against anti-cancer drugs in cultured human colon cancer cells. By characterizing PKC isozyme expression in the cells and the induction of resistance by isozyme-selective PKC activators, we have obtained evidence that the induction of resistance is triggered by phorbol-ester activation of cPKC-alpha. We have also found that cPKC-alpha is expressed abundantly in surgical specimens of human colon cancer, indicating that cPKC-alpha-mediated drug resistance may contribute to the intrinsic drug resistance of clinical colon cancer. The intrinsic resistance of human colon cancer to multiple anticancer drugs precludes effective therapy of disseminated disease with available chemotherapeutic regimens. The development of reversal agents of intrinsic drug resistance that function by selective inhibition of cPKC-alpha might allow successful management of the disease with standard cytotoxic chemotherapeutic regimens.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0361-7742
pubmed:author
pubmed:issnType
Print
pubmed:volume
391
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
117-20
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
The tumor promoter receptor protein kinase C: a novel target for chemoprevention and therapy of human colon cancer.
pubmed:affiliation
Department of Cell Biology, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review, Research Support, Non-U.S. Gov't