Linked Life Data

8531507

Source:http://linkedlifedata.com/resource/pubmed/id/8531507

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1996-1-30
pubmed:abstractText
The toxicity of hyperbaric oxygen in the central nervous system is expressed by generalized tonic-clonic seizures. In the search for drugs effective against these seizures, we tested flumazenil, a benzodiazepine antagonist known to have antiepileptic properties. Forty rats with chronic cortical electrodes were injected i.p. with one of three doses of flumazenil (0.2, 2, and 20 mg/kg) or their vehicle, before exposure to 0.5 MPa oxygen. EEG and the spectral analysis of background EEG activity were monitored. The duration of the latent period until the appearance of electrical discharges in the EEG was used as an index of oxygen toxicity. Significant prolongation of the latent period preceding oxygen seizures was noted in the group of rats treated with 0.2 mg/kg flumazenil (p < 0.05 in Tukey test). However, when the dose of flumazenil was increased, the duration of the latent period returned to control values. These diverse effects of flumazenil on the benzodiazepine receptor may account for its complex effects on hyperoxic-induced seizures.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0379-0355
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
169-74
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
The effect of flumazenil on CNS oxygen toxicity in the rat.
pubmed:affiliation
Israel Naval Medical Institute, Haifa.
pubmed:publicationType
Journal Article