|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1996-1-24
|
|
pubmed:abstractText |
Stimulation of synaptoneurosome suspensions by the neurotransmitter glutamate gives rise to rapid loading of ribosomes onto mRNA and increased incorporation of amino acids into trichloroacetic acid-precipitable polypeptides. Metabotropic glutamate receptors (mGluRs) are responsible for this effect. Although simultaneous Ca2+ entry and mGluR stimulation do not change the response, entry of Ca2+ 30 s or 3 min before mGluR stimulation markedly depresses the polyribosomal loading. Either NMDA or ionophore (A23187) produces the depression. A calmodulin antagonist, W7, alleviates the effect, suggesting that inactivation of phospholipase A2 by calcium-calmodulin-dependent kinase II is partially responsible for the phenomenon. Thus, interaction between different classes of glutamate receptors affects the control of protein translation at the synapse. This effect may partially explain recent observations of negative interactions between receptor classes in induction of long-term potentiation.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1-amino-1,3-dicarboxycyclopentane,
http://linkedlifedata.com/resource/pubmed/chemical/6-Cyano-7-nitroquinoxaline-2,3-dione,
http://linkedlifedata.com/resource/pubmed/chemical/Calcimycin,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent...,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent...,
http://linkedlifedata.com/resource/pubmed/chemical/Calmodulin,
http://linkedlifedata.com/resource/pubmed/chemical/Cycloleucine,
http://linkedlifedata.com/resource/pubmed/chemical/Ionophores,
http://linkedlifedata.com/resource/pubmed/chemical/N-Methylaspartate,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phorbol 12,13-Dibutyrate,
http://linkedlifedata.com/resource/pubmed/chemical/Phospholipases A,
http://linkedlifedata.com/resource/pubmed/chemical/Phospholipases A2,
http://linkedlifedata.com/resource/pubmed/chemical/Quisqualic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Metabotropic Glutamate,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides,
http://linkedlifedata.com/resource/pubmed/chemical/W 7
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0022-3042
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
66
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
197-202
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:8522953-6-Cyano-7-nitroquinoxaline-2,3-dione,
pubmed-meshheading:8522953-Animals,
pubmed-meshheading:8522953-Calcimycin,
pubmed-meshheading:8522953-Calcium,
pubmed-meshheading:8522953-Calcium-Calmodulin-Dependent Protein Kinase Type 2,
pubmed-meshheading:8522953-Calcium-Calmodulin-Dependent Protein Kinases,
pubmed-meshheading:8522953-Calmodulin,
pubmed-meshheading:8522953-Cerebral Cortex,
pubmed-meshheading:8522953-Cycloleucine,
pubmed-meshheading:8522953-Depression, Chemical,
pubmed-meshheading:8522953-Gene Expression Regulation,
pubmed-meshheading:8522953-Ionophores,
pubmed-meshheading:8522953-Long-Term Potentiation,
pubmed-meshheading:8522953-N-Methylaspartate,
pubmed-meshheading:8522953-Nerve Tissue Proteins,
pubmed-meshheading:8522953-Phorbol 12,13-Dibutyrate,
pubmed-meshheading:8522953-Phospholipases A,
pubmed-meshheading:8522953-Phospholipases A2,
pubmed-meshheading:8522953-Protein Biosynthesis,
pubmed-meshheading:8522953-Quisqualic Acid,
pubmed-meshheading:8522953-RNA, Messenger,
pubmed-meshheading:8522953-Rats,
pubmed-meshheading:8522953-Receptors, Metabotropic Glutamate,
pubmed-meshheading:8522953-Ribosomes,
pubmed-meshheading:8522953-Sulfonamides,
pubmed-meshheading:8522953-Synapses
|
|
pubmed:year |
1996
|
|
pubmed:articleTitle |
Calcium ion impedes translation initiation at the synapse.
|
|
pubmed:affiliation |
Department of Psychology, Beckman Institute, University of Illinois at Urbana-Champaign.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
